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2015 ; 94
(36
): e1462
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Performance of Positron Emission Tomography and Positron Emission
Tomography/Computed Tomography Using Fluorine-18-Fluorodeoxyglucose for the
Diagnosis, Staging, and Recurrence Assessment of Bone Sarcoma: A Systematic
Review and Meta-Analysis
#MMPMID26356700
Liu F
; Zhang Q
; Zhu D
; Liu F
; Li Z
; Li J
; Wang B
; Zhou D
; Dong J
Medicine (Baltimore)
2015[Sep]; 94
(36
): e1462
PMID26356700
show ga
To investigate the performance of fluorine-18-fluorodeoxyglucose (F-FDG) positron
emission tomography (PET) and PET/computed tomography (CT) in the diagnosis,
staging, restaging, and recurrence surveillance of bone sarcoma by systematically
reviewing and meta-analyzing the published literature.To retrieve eligible
studies, we searched the MEDLINE, Embase, and the Cochrane Central library
databases using combinations of following Keywords: "positron emission
tomography" or "PET," and "bone tumor" or "bone sarcoma" or "sarcoma."
Bibliographies from relevant articles were also screened manually. Data were
extracted and the pooled sensitivity, specificity, and diagnostic odds ratio
(DOR), on an examination-based or lesion-based level, were calculated to appraise
the diagnostic accuracy of F-FDG PET and PET/CT. All statistical analyses were
performed using Meta-Disc 1.4.Forty-two trials were eligible. The pooled
sensitivity and specificity of PET/CT to differentiate primary bone sarcomas from
benign lesions were 96% (95% confidence interval [CI], 93-98) and 79% (95% CI,
63-90), respectively. For detecting recurrence, the pooled results on an
examination-based level were sensitivity 92% (95% CI, 85-97), specificity 93%
(95% CI, 88-96), positive likelihood ratio (PLR) 10.26 (95% CI, 5.99-17.60), and
negative likelihood ratio (NLR) 0.11 (95% CI, 0.05-0.22). For detecting distant
metastasis, the pooled results on a lesion-based level were sensitivity 90% (95%
CI, 86-93), specificity 85% (95% CI, 81-87), PLR 5.16 (95% CI, 2.37-11.25), and
NLR 0.15 (95% CI, 0.11-0.20). The accuracies of PET/CT for detecting local
recurrence, lung metastasis, and bone metastasis were satisfactory. Pooled
outcome estimates of F-FDG PET were less complete compared with those of
PET/CT.F-FDG PET and PET/CT showed a high sensitivity for diagnosing primary bone
sarcoma. Moreover, PET/CT demonstrated excellent accuracy for the staging,
restaging, and recurrence surveillance of bone sarcoma. However, to avoid
misdiagnosis, pathological examination or long-term follow-up should be carried
out for F-FDG-avid lesions in patients with suspected bone sarcoma.