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10.1097/MD.0000000000001433 http://scihub22266oqcxt.onion/10.1097/MD.0000000000001433 C4616624!4616624 !26356697     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26356697 &cmd=llinks): Failed to open stream: HTTP request failed! 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Nodal Basin Recurrence After Sentinel Lymph Node Biopsy for Melanoma: A Retrospective Multicenter Study in 2653 Patients |pdf=|usr=}}{{26356697 }} gab.com Text Nodal Basin Recurrence After Sentinel Lymph Node Biopsy for Melanoma: A Retrospective Multicenter Study in 2653 Patients JO: Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=26356697 #FOAvip The objective of this study was to analyze different types of nodal basin recurrence after sentinel lymph node biopsy (SLNB) for melanoma. PATIENTS AND METHODS: Kaplan-Meier estimates and the Cox proportional hazards model were used to study 2653 patients from 3 German melanoma centers retrospectively.The estimated 5-year negative predictive value of SLNB was 96.4%. The estimated false-negative (FN) rates after 1, 2, 3, 5, and 10 years were 2.5%, 4.6%, 6.4%, 8.7%, and 12.6%, respectively. Independent factors associated with false negativity were older age, fewer SLNs excised, and head or neck location of the primary tumor. Compared with SLN-positive patients, the FNs had a significantly lower survival. In SLN-positive patients undergoing completion lymphadenectomy (CLND), the 5-year nodal basin recurrence rate was 18.3%. The recurrence rates for axilla, groin, and neck were 17.2%, 15.5%, and 44.1%, respectively. Significant factors predicting local relapse after CLND were older age, head, or neck location of the primary tumor, ulceration, deeper penetration of the metastasis into the SLN, tumor-positive CLND, and >2 lymph node metastases. All kinds of nodal relapse were associated with a higher prevalence of in-transit metastases.The FN rate after SLNB steadily increases over the observation period and should, therefore, be estimated by the Kaplan-Meier method. False-negativity is associated with fewer SLNs excised. The beneficial effect of CLND on nodal basin disease control varies considerably across different risk groups. This should be kept in mind about SLN-positive patients when individual decisions on prophylactic CLND are taken. Twit Text FOAVip Nodal Basin Recurrence After Sentinel Lymph Node Biopsy for Melanoma: A Retrospective Multicenter Study in 2653 Patients ????Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=26356697 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26356697 #FOAvip English Wikipedia <ref>{{Cite pmid|26356697 }}</ref> Nodal Basin Recurrence After Sentinel Lymph Node Biopsy for Melanoma: A Retrospective Multicenter Study in 2653 Patients #MMPMID26356697 Kretschmer L ; Bertsch HP ; Zapf A ; Mitteldorf C ; Satzger I ; Thoms KM ; Völker B ; Schön MP ; Gutzmer R ; Starz H Medicine (Baltimore) 2015[Sep]; 94 (36 ): e1433 PMID26356697 show ga The objective of this study was to analyze different types of nodal basin recurrence after sentinel lymph node biopsy (SLNB) for melanoma. PATIENTS AND METHODS: Kaplan-Meier estimates and the Cox proportional hazards model were used to study 2653 patients from 3 German melanoma centers retrospectively.The estimated 5-year negative predictive value of SLNB was 96.4%. The estimated false-negative (FN) rates after 1, 2, 3, 5, and 10 years were 2.5%, 4.6%, 6.4%, 8.7%, and 12.6%, respectively. Independent factors associated with false negativity were older age, fewer SLNs excised, and head or neck location of the primary tumor. Compared with SLN-positive patients, the FNs had a significantly lower survival. In SLN-positive patients undergoing completion lymphadenectomy (CLND), the 5-year nodal basin recurrence rate was 18.3%. The recurrence rates for axilla, groin, and neck were 17.2%, 15.5%, and 44.1%, respectively. Significant factors predicting local relapse after CLND were older age, head, or neck location of the primary tumor, ulceration, deeper penetration of the metastasis into the SLN, tumor-positive CLND, and >2 lymph node metastases. All kinds of nodal relapse were associated with a higher prevalence of in-transit metastases.The FN rate after SLNB steadily increases over the observation period and should, therefore, be estimated by the Kaplan-Meier method. False-negativity is associated with fewer SLNs excised. The beneficial effect of CLND on nodal basin disease control varies considerably across different risk groups. This should be kept in mind about SLN-positive patients when individual decisions on prophylactic CLND are taken. |*Lymph Node Excision/adverse effects/methods [MESH] |*Lymphatic Metastasis/diagnosis/prevention & control [MESH] |*Melanoma/epidemiology/pathology [MESH] |*Neoplasm Recurrence, Local/diagnosis/prevention & control [MESH] |*Sentinel Lymph Node Biopsy/methods/statistics & numerical data [MESH] |Adult [MESH] |Aged [MESH] |Female [MESH] |Germany/epidemiology [MESH] |Humans [MESH] |Kaplan-Meier Estimate [MESH] |Lymph Nodes/pathology/surgery [MESH] |Male [MESH] |Middle Aged [MESH] |Neoplasm Staging [MESH] |Prognosis [MESH] |Retrospective Studies [MESH]Nodal Basin Recurrence After Sentinel Lymph Node Biopsy for Melanoma: (epmc).pdf DeepDyve Pubget Overpricing