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2015 ; 94
(31
): e1326
Nephropedia Template TP
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Role of Micro RNAs in the Pathogenesis of Rheumatoid Arthritis: Novel
Perspectives Based on Review of the Literature
#MMPMID26252320
Chen XM
; Huang QC
; Yang SL
; Chu YL
; Yan YH
; Han L
; Huang Y
; Huang RY
Medicine (Baltimore)
2015[Aug]; 94
(31
): e1326
PMID26252320
show ga
The contributions of micro RNAs (miRNAs) to rheumatoid arthritis (RA) are
beginning to be uncovered during the last decade. Many studies in efforts to use
miRNAs as biomarkers in disease diagnosis, prognosis, and treatment are
ongoing.We conducted a systematic literature review to reveal the role of miRNAs
in the pathogenesis of RA in order to inform future research.We analyzed all the
literature which is searched by keywords "microRNA" and "arthritis" in PubMed
from December 2007 to June 2015, and the references cited by the articles
searched were also considered.Relevant literature focusing on the field of miRNAs
and RA was identified. The searching process was conducted by 5 independent
investigators. The experts in the field of miRNAs and Rheumatology were involved
in the process of analyzing.Relevant literature was analyzed according to the
objective of this review and the availability of full text.The crucial role of
miRNAs in maintaining immune and inflammatory responses is revealed. In addition,
it is now clear that miRNAs are implicated in the development of RA synovial
phenotype including synovial hyperplasia and joint destruction. Intriguingly, the
biomedical application of several miRNAs may result in the effects of
"double-edged sword." Moreover, there appears to have a feedback loop for
expression of some miRNAs related to disease activity in inflammatory milieu of
rheumatoid joint.This review underscores the potential importance of miRNAs to
diagnosis, prognosis, and treatment of RA. Further investigations are required to
identify the unique miRNAs signatures in RA and characterize the mechanisms
mediated by miRNAs in the pathology of RA.
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