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10.1097/MD.0000000000001274

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C4616582!4616582 !26252295
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suck abstract from ncbi


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pmid26252295
      Medicine+(Baltimore) 2015 ; 94 (31 ): e1274
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  • Posttransplant Lymphoproliferative Disorder of the Thorax: CT and FDG-PET Features in a Single Tertiary Referral Center #MMPMID26252295
  • Yoon GY ; Kim MY ; Huh JR ; Jo KW ; Shim TS
  • Medicine (Baltimore) 2015[Aug]; 94 (31 ): e1274 PMID26252295 show ga
  • To investigate the chest computed tomography (CT) and F-18 fluoro-2-deoxy-D-glucose positron emission tomographic (FDG-PET) findings of posttransplant lymphoproliferative disorder (PTLD) in the thorax.From November 2004 to February 2013, the cases of 12 adult patients (3 female and 9 male, age range 34-68, and median age 46 years) with proven PTLD were retrospectively reviewed. The transplanted organs included the kidney (5/12), liver (4/12), heart (1/12), combined kidney and pancreas (1/12), and hematopoietic stem cell (1/12). We investigated the relationship of the Epstein-Barr virus (EBV) to the patients' long-term follow-up, and evaluated the characteristics of the lesions on the chest CT and FDG-PET. The lesions were classified into 2 patterns: that of lymph node and lung involvement.The interval between the transplantation and the onset of PTLD was 2 to 128 months (median, 49). Positive EBV-encoded RNA in the pathologic specimens was found in 10 patients (83.3%). Eight patients were positive for EBV PCR in their blood, and 3 patients showed seroconversion without antiviral therapy. The responses to treatment were complete in 7 cases (58.3%), partial remission in 4 cases (33.3%), and undetermined in 1 case (8.3%). The more common chest CT patterns showed lymph node involvement (10/12) rather than lung involvement (3/12). The median maximum-standardized uptake value on the FDG-PET scans was 7.7 (range, 2.7-25.5).In patients with PTLD involving the thorax, lymphadenopathy was the more common manifestation on the chest CT rather than lung involvement. The lesions showed hypermetabolism on FDG-PET.
  • |*Positron-Emission Tomography [MESH]
  • |*Thorax [MESH]
  • |*Tomography, X-Ray Computed [MESH]
  • |Adult [MESH]
  • |Aged [MESH]
  • |Female [MESH]
  • |Fluorodeoxyglucose F18 [MESH]
  • |Humans [MESH]
  • |Lymphoproliferative Disorders/*diagnostic imaging/etiology [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Organ Transplantation/*adverse effects [MESH]
  • |Radiopharmaceuticals [MESH]
  • |Retrospective Studies [MESH]


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