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2015 ; 94
(31
): e1274
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Posttransplant Lymphoproliferative Disorder of the Thorax: CT and FDG-PET
Features in a Single Tertiary Referral Center
#MMPMID26252295
Yoon GY
; Kim MY
; Huh JR
; Jo KW
; Shim TS
Medicine (Baltimore)
2015[Aug]; 94
(31
): e1274
PMID26252295
show ga
To investigate the chest computed tomography (CT) and F-18
fluoro-2-deoxy-D-glucose positron emission tomographic (FDG-PET) findings of
posttransplant lymphoproliferative disorder (PTLD) in the thorax.From November
2004 to February 2013, the cases of 12 adult patients (3 female and 9 male, age
range 34-68, and median age 46 years) with proven PTLD were retrospectively
reviewed. The transplanted organs included the kidney (5/12), liver (4/12), heart
(1/12), combined kidney and pancreas (1/12), and hematopoietic stem cell (1/12).
We investigated the relationship of the Epstein-Barr virus (EBV) to the patients'
long-term follow-up, and evaluated the characteristics of the lesions on the
chest CT and FDG-PET. The lesions were classified into 2 patterns: that of lymph
node and lung involvement.The interval between the transplantation and the onset
of PTLD was 2 to 128 months (median, 49). Positive EBV-encoded RNA in the
pathologic specimens was found in 10 patients (83.3%). Eight patients were
positive for EBV PCR in their blood, and 3 patients showed seroconversion without
antiviral therapy. The responses to treatment were complete in 7 cases (58.3%),
partial remission in 4 cases (33.3%), and undetermined in 1 case (8.3%). The more
common chest CT patterns showed lymph node involvement (10/12) rather than lung
involvement (3/12). The median maximum-standardized uptake value on the FDG-PET
scans was 7.7 (range, 2.7-25.5).In patients with PTLD involving the thorax,
lymphadenopathy was the more common manifestation on the chest CT rather than
lung involvement. The lesions showed hypermetabolism on FDG-PET.