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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2015 ; 94
(24
): e1031
Nephropedia Template TP
gab.com Text
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English Wikipedia
The Role of Spleen Stiffness in Determining the Severity and Bleeding Risk of
Esophageal Varices in Cirrhotic Patients
#MMPMID26091449
Kim HY
; Jin EH
; Kim W
; Lee JY
; Woo H
; Oh S
; Seo JY
; Oh HS
; Chung KH
; Jung YJ
; Kim D
; Kim BG
; Lee KL
Medicine (Baltimore)
2015[Jun]; 94
(24
): e1031
PMID26091449
show ga
Esophageal varix and its hemorrhage are serious complications of liver cirrhosis.
Recent studies have focused on noninvasive prediction of esophageal varices. We
attempted to evaluate the association of liver and spleen stiffness (LS and SS)
as measured by acoustic radiation force impulse imaging, with the presence and
severity of esophageal varices and variceal hemorrhage in cirrhotic patients. We
measured LS and SS, along with endoscopic examination of esophageal varices for a
total of 125 cirrhotic patients at a single referral hospital in this prospective
observational study. The diagnostic utility of noninvasive methods for
identifying varices and their bleeding risk was compared, including LS, SS,
spleen length, Child-Pugh score, and various serum fibrosis indices. Esophageal
varices were present in 77 patients (61.6%). SS was significantly higher in
patients with varices than in those without varices (3.58 ± 0.47 vs 3.02 ± 0.49;
P < 0.001). A tendency toward increasing SS levels was observed with increasing
severity of varices (no varix, 3.02 ± 0.49; F1, 3.39 ± 0.51; F2, 3.60 ± 0.42; F3,
3.85 ± 0.37; P < 0.001). SS was significantly higher in patients who experienced
variceal hemorrhage than in those who did not (3.80 ± 0.36 vs 3.20 ± 0.51; P =
0.002). An optimal cut-off value of SS for high-risk varices (? F2) or variceal
hemorrhage was 3.40 m/s. SS was significantly correlated with the presence,
severity, and bleeding risk of esophageal varices. Prompt endoscopic evaluation
of variceal status and prophylactic measures based on the SS may be warranted for
cirrhotic patients.
|Aged
[MESH]
|Elasticity Imaging Techniques
[MESH]
|Esophageal and Gastric Varices/*etiology/*physiopathology
[MESH]