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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2015 ; 94
(35
): e1458
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English Wikipedia
Increased Risk of Hemorrhagic and Ischemic Strokes in Patients With Splenic
Injury and Splenectomy: A Nationwide Cohort Study
#MMPMID26334909
Lin JN
; Lin CL
; Lin MC
; Lai CH
; Lin HH
; Yang CH
; Kao CH
Medicine (Baltimore)
2015[Sep]; 94
(35
): e1458
PMID26334909
show ga
The spleen is a crucial organ in humans. Little is known about the association
between stroke and splenic injury or splenectomy. The aim of this study was to
determine the risk of stroke in patients with splenic injury and splenectomy.A
nationwide cohort study was conducted by analyzing the National Health Insurance
Research Database in Taiwan. For comparison, control patients were selected and
matched with splenic injury patients in a ratio of 4:1 according to age, sex, and
the year of hospitalization. We analyzed the risks of stroke using a Cox
proportional-hazards regression analysis.A total of 11,273 splenic injury
patients, including 5294 splenectomized and 5979 nonsplenectomized patients, and
45,092 control patients were included in this study. The incidence rates of
stroke were 8.05, 6.53, and 4.25 per 1000 person-years in splenic injury patients
with splenectomy, those without splenectomy, and the control cohort,
respectively. Compared with the control cohort, splenic injury patients with
splenectomy exhibited a 2.05-fold increased risk of stroke (95% confidence
interval [CI] 1.8-2.34), whereas those without splenectomy exhibited a 1.74-fold
increased risk (95% CI 1.51-2). Splenectomy entailed an additional 1.21-fold
increased risk of stroke compared with nonsplenectomy in patients with splenic
injury.This study revealed that splenic injury and splenectomy were significantly
associated with an increased risk of hemorrhagic and ischemic strokes. The
results of this study may alert physicians and patients to the complications of
splenic injury and splenectomy.