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10.1097/MD.0000000000000866 http://scihub22266oqcxt.onion/10.1097/MD.0000000000000866 C4616360!4616360!26039116     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Medicine+(Baltimore) 2015 ; 94 (22): ä Nephropedia Template TP {{tp|p=26039116|t=2015. Dermatopathic Lymphadenopathy With Increased IgG4-Positive Plasma Cells |pdf=|usr=}}{{26039116}} gab.com Text Dermatopathic Lymphadenopathy With Increased IgG4-Positive Plasma Cells JO: Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=26039116 #FOAvip Both dermatopathic lymphadenopathy (DL) and immunoglobulin G4-related disease (IgG4-RD) are frequently complicated with allergic diseases. However, the relationship between DL and IgG4-RD is not well known. To clarify this relationship on the basis of clinical and pathological findings, including IgG4-positive (IgG4+) plasma cell infiltration in lymph nodes (LNs) of DL patients, we analyzed LNs of 11 DL patients using immunostaining of IgG, IgG4, forkhead box P3 (FOXP3), transforming growth factor (TGF)-?, interferon (IFN)-?, and matrix metalloproteinase (MMP)-1, MMP-8, and MMP-13. Toluidine blue staining was also performed to identify mast cells. Of 3 patients with a high ratio of IgG4+/IgG+ cells (>40%) and elevated serum IgG4 levels, 2 developed IgG4-RD, whereas the other patient did not. Of 8 patients with a low ratio of IgG4+/IgG+ cells (<40%) or no infiltration of IgG4+ cells, 5 who could be followed did not develop IgG4-RD. The numbers of mast cells were similar to those of TGF-?-positive cells, and serial sections showed that mast cells possibly produce TGF-?. LNs of DL patients with a high ratio of IgG4+/IgG+ cells had significantly more mast cells and TGF-?-positive cells than those of patients with a low ratio of IgG4+/IgG+ cells or no infiltration of IgG4+ cells. However, no fibrosis was observed in LNs of both groups. IFN-? was positive in interdigitating dendritic cells, Langerhans cells, and macrophages. MMP-1, MMP-8, or MMP-13 was expressed in macrophages. The lack of fibrosis in LNs may have been due to the production of IFN-?, MMP-1, MMP-8, or MMP-13. Thus, DL with increased IgG4+ cells seems to be a phenotype of IgG4-RD in LNs. Twit Text FOAVip Dermatopathic Lymphadenopathy With Increased IgG4-Positive Plasma Cells ????Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=26039116 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26039116 #FOAvip English Wikipedia <ref>{{Cite pmid|26039116}}</ref> Dermatopathic Lymphadenopathy With Increased IgG4-Positive Plasma Cells #MMPMID26039116 Nakayama S; Yokote T; Akioka T; Miyoshi T; Hirata Y; Hiraoka N; Iwaki K; Takayama A; Nishiwaki U; Masuda Y; Hanafusa T; Nishimura Y; Tsuji M Medicine (Baltimore) 2015[Jun]; 94 (22): ä PMID26039116show ga Both dermatopathic lymphadenopathy (DL) and immunoglobulin G4-related disease (IgG4-RD) are frequently complicated with allergic diseases. However, the relationship between DL and IgG4-RD is not well known. To clarify this relationship on the basis of clinical and pathological findings, including IgG4-positive (IgG4+) plasma cell infiltration in lymph nodes (LNs) of DL patients, we analyzed LNs of 11 DL patients using immunostaining of IgG, IgG4, forkhead box P3 (FOXP3), transforming growth factor (TGF)-?, interferon (IFN)-?, and matrix metalloproteinase (MMP)-1, MMP-8, and MMP-13. Toluidine blue staining was also performed to identify mast cells. Of 3 patients with a high ratio of IgG4+/IgG+ cells (>40%) and elevated serum IgG4 levels, 2 developed IgG4-RD, whereas the other patient did not. Of 8 patients with a low ratio of IgG4+/IgG+ cells (<40%) or no infiltration of IgG4+ cells, 5 who could be followed did not develop IgG4-RD. The numbers of mast cells were similar to those of TGF-?-positive cells, and serial sections showed that mast cells possibly produce TGF-?. LNs of DL patients with a high ratio of IgG4+/IgG+ cells had significantly more mast cells and TGF-?-positive cells than those of patients with a low ratio of IgG4+/IgG+ cells or no infiltration of IgG4+ cells. However, no fibrosis was observed in LNs of both groups. IFN-? was positive in interdigitating dendritic cells, Langerhans cells, and macrophages. MMP-1, MMP-8, or MMP-13 was expressed in macrophages. The lack of fibrosis in LNs may have been due to the production of IFN-?, MMP-1, MMP-8, or MMP-13. Thus, DL with increased IgG4+ cells seems to be a phenotype of IgG4-RD in LNs. äDermatopathic Lymphadenopathy With Increased IgG4-Positive Plasma Cell(epmc).pdf DeepDyve Pubget Overpricing