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10.1097/MD.0000000000000094

http://scihub22266oqcxt.onion/10.1097/MD.0000000000000094
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C4616315!4616315 !25396335
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suck abstract from ncbi


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pmid25396335
      Medicine+(Baltimore) 2014 ; 93 (22 ): e94
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  • Surgical treatment and clinical outcome of nonfunctional pancreatic neuroendocrine tumors: a 14-year experience from one single center #MMPMID25396335
  • Yang M ; Zeng L ; Zhang Y ; Su AP ; Yue PJ ; Tian BL
  • Medicine (Baltimore) 2014[Nov]; 93 (22 ): e94 PMID25396335 show ga
  • Our primary aim of the present study was to analyze the clinical characteristics and surgical outcome of nonfunctional pancreatic neuroendocrine tumors (non-F-P-NETs), with an emphasis on evaluating the prognostic value of the newly updated 2010 grading classification of the World Health Organization (WHO).Data of 55 consecutive patients who were surgically treated and pathologically diagnosed as non-F-P-NETs in our single institution from January 2000 to December 2013 were retrospectively collected.This entirety comprised of 55 patients (31 males and 24 females), with a mean age of 51.24 ± 12.95 years. Manifestations of non-F-P-NETs were nonspecific. Distal pancreatectomy, pancreaticoduodenectomy, and local resection of pancreatic tumor were the most frequent surgical procedures, while pancreatic fistula was the most common but acceptable complication (30.3%). The overall 5-year survival rate of this entire cohort was 41.0%, with a median survival time of 60.4 months. Patients who underwent R0 resections obtained a better survival than those who did not (P < 0.005). As for the prognostic analysis, tumor size and lymph invasion were only statistically significant in univariate analysis (P = 0.046 and P < 0.05, respectively), whereas the newly updated 2010 grading classification of WHO (G1 and G2 vs G3), distant metastasis, and surgical margin were all meaningful in both univariate and multivariate analysis (P = 0.045, 0.001, and 0.042, respectively).Non-F-P-NETs are a kind of rare neoplasm, with mostly indolent malignancy. Patients with non-F-P-NETs could benefit from the radical resections. The new WHO criteria, distant metastasis and surgical margin, might be independent predictors for the prognosis of non-F-P-NETs.
  • |*Pancreatectomy [MESH]
  • |Adolescent [MESH]
  • |Adult [MESH]
  • |Aged [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Pancreatic Neoplasms/diagnosis/mortality/*surgery [MESH]
  • |Prognosis [MESH]
  • |Retrospective Studies [MESH]
  • |Survival Rate [MESH]
  • |Time Factors [MESH]
  • |Treatment Outcome [MESH]


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