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2014 ; 93
(22
): e94
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Surgical treatment and clinical outcome of nonfunctional pancreatic
neuroendocrine tumors: a 14-year experience from one single center
#MMPMID25396335
Yang M
; Zeng L
; Zhang Y
; Su AP
; Yue PJ
; Tian BL
Medicine (Baltimore)
2014[Nov]; 93
(22
): e94
PMID25396335
show ga
Our primary aim of the present study was to analyze the clinical characteristics
and surgical outcome of nonfunctional pancreatic neuroendocrine tumors
(non-F-P-NETs), with an emphasis on evaluating the prognostic value of the newly
updated 2010 grading classification of the World Health Organization (WHO).Data
of 55 consecutive patients who were surgically treated and pathologically
diagnosed as non-F-P-NETs in our single institution from January 2000 to December
2013 were retrospectively collected.This entirety comprised of 55 patients (31
males and 24 females), with a mean age of 51.24 ± 12.95 years. Manifestations of
non-F-P-NETs were nonspecific. Distal pancreatectomy, pancreaticoduodenectomy,
and local resection of pancreatic tumor were the most frequent surgical
procedures, while pancreatic fistula was the most common but acceptable
complication (30.3%). The overall 5-year survival rate of this entire cohort was
41.0%, with a median survival time of 60.4 months. Patients who underwent R0
resections obtained a better survival than those who did not (P < 0.005). As for
the prognostic analysis, tumor size and lymph invasion were only statistically
significant in univariate analysis (P = 0.046 and P < 0.05, respectively),
whereas the newly updated 2010 grading classification of WHO (G1 and G2 vs G3),
distant metastasis, and surgical margin were all meaningful in both univariate
and multivariate analysis (P = 0.045, 0.001, and 0.042,
respectively).Non-F-P-NETs are a kind of rare neoplasm, with mostly indolent
malignancy. Patients with non-F-P-NETs could benefit from the radical resections.
The new WHO criteria, distant metastasis and surgical margin, might be
independent predictors for the prognosis of non-F-P-NETs.