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10.1097/MD.0000000000000018 http://scihub22266oqcxt.onion/10.1097/MD.0000000000000018 C4616306!4616306 !24646463     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24646463 &cmd=llinks): Failed to open stream: HTTP request failed! 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Early- versus late-onset systemic sclerosis: differences in clinical presentation and outcome in 1037 patients |pdf=|usr=}}{{24646463 }} gab.com Text Early- versus late-onset systemic sclerosis: differences in clinical presentation and outcome in 1037 patients JO: Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=24646463 #FOAvip Peak age at onset of systemic sclerosis (SSc) is between 20 and 50 years, although SSc is also described in both young and elderly patients. We conducted the present study to determine if age at disease onset modulates the clinical characteristics and outcome of SSc patients. The Spanish Scleroderma Study Group recruited 1037 patients with a mean follow-up of 5.2 ± 6.8 years. Based on the mean ± 1 standard deviation (SD) of age at disease onset (45 ± 15 yr) of the whole series, patients were classified into 3 groups: age ? 30 years (early onset), age between 31 and 59 years (standard onset), and age ? 60 years (late onset). We compared initial and cumulative manifestations, immunologic features, and death rates. The early-onset group included 195 patients; standard-onset group, 651; and late-onset, 191 patients. The early-onset group had a higher prevalence of esophageal involvement (72% in early-onset compared with 67% in standard-onset and 56% in late-onset; p = 0.004), and myositis (11%, 7.2%, and 2.9%, respectively; p = 0.009), but a lower prevalence of centromere antibodies (33%, 46%, and 47%, respectively; p = 0.007). In contrast, late-onset SSc was characterized by a lower prevalence of digital ulcers (54%, 41%, and 34%, respectively; p < 0.001) but higher rates of heart conduction system abnormalities (9%, 13%, and 21%, respectively; p = 0.004). Pulmonary hypertension was found in 25% of elderly patients and in 12% of the youngest patients (p = 0.010). After correction for the population effects of age and sex, standardized mortality ratio was shown to be higher in younger patients. The results of the present study confirm that age at disease onset is associated with differences in clinical presentation and outcome in SSc patients. Twit Text FOAVip Early- versus late-onset systemic sclerosis: differences in clinical presentation and outcome in 1037 patients ????Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=24646463 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24646463 #FOAvip English Wikipedia <ref>{{Cite pmid|24646463 }}</ref> Early- versus late-onset systemic sclerosis: differences in clinical presentation and outcome in 1037 patients #MMPMID24646463 Alba MA ; Velasco C ; Simeón CP ; Fonollosa V ; Trapiella L ; Egurbide MV ; Sáez L ; Castillo MJ ; Callejas JL ; Camps MT ; Tolosa C ; Ríos JJ ; Freire M ; Vargas JA ; Espinosa G Medicine (Baltimore) 2014[Mar]; 93 (2 ): 73-81 PMID24646463 show ga Peak age at onset of systemic sclerosis (SSc) is between 20 and 50 years, although SSc is also described in both young and elderly patients. We conducted the present study to determine if age at disease onset modulates the clinical characteristics and outcome of SSc patients. The Spanish Scleroderma Study Group recruited 1037 patients with a mean follow-up of 5.2 ± 6.8 years. Based on the mean ± 1 standard deviation (SD) of age at disease onset (45 ± 15 yr) of the whole series, patients were classified into 3 groups: age ? 30 years (early onset), age between 31 and 59 years (standard onset), and age ? 60 years (late onset). We compared initial and cumulative manifestations, immunologic features, and death rates. The early-onset group included 195 patients; standard-onset group, 651; and late-onset, 191 patients. The early-onset group had a higher prevalence of esophageal involvement (72% in early-onset compared with 67% in standard-onset and 56% in late-onset; p = 0.004), and myositis (11%, 7.2%, and 2.9%, respectively; p = 0.009), but a lower prevalence of centromere antibodies (33%, 46%, and 47%, respectively; p = 0.007). In contrast, late-onset SSc was characterized by a lower prevalence of digital ulcers (54%, 41%, and 34%, respectively; p < 0.001) but higher rates of heart conduction system abnormalities (9%, 13%, and 21%, respectively; p = 0.004). Pulmonary hypertension was found in 25% of elderly patients and in 12% of the youngest patients (p = 0.010). After correction for the population effects of age and sex, standardized mortality ratio was shown to be higher in younger patients. The results of the present study confirm that age at disease onset is associated with differences in clinical presentation and outcome in SSc patients. |Adult [MESH] |Age of Onset [MESH] |Female [MESH] |Humans [MESH] |Male [MESH] |Middle Aged [MESH] |Risk Factors [MESH] |Scleroderma, Systemic/*complications/*physiopathology [MESH]Early- versus late-onset systemic sclerosis: differences in clinical p(epmc).pdf DeepDyve Pubget Overpricing