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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2014 ; 93
(2
): 106-113
Nephropedia Template TP
gab.com Text
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English Wikipedia
Henoch-Schönlein purpura in northern Spain: clinical spectrum of the disease in
417 patients from a single center
#MMPMID24646467
Calvo-Río V
; Loricera J
; Mata C
; Martín L
; Ortiz-Sanjuán F
; Alvarez L
; González-Vela MC
; González-Lamuño D
; Rueda-Gotor J
; Fernández-Llaca H
; González-López MA
; Armesto S
; Peiró E
; Arias M
; González-Gay MA
; Blanco R
Medicine (Baltimore)
2014[Mar]; 93
(2
): 106-113
PMID24646467
show ga
The severity of clinical features and the outcomes in previous series of patients
reported with Henoch-Schönlein purpura (HSP) vary greatly, probably due to
selection bias. To establish the actual clinical spectrum of HSP in all age
groups using an unselected and wide series of patients diagnosed at a single
center, we performed a retrospective review of 417 patients classified as having
HSP according to the criteria proposed by Michel et al. Of 417 patients, 240 were
male and 177 female, with a median age at the time of disease diagnosis of 7.5
years (interquartile range [IQR], 5.3-20.1 yr). Three-quarters of the patients
were children or young people aged 20 years or younger (n = 315), and one-quarter
were adults (n = 102). The most frequent precipitating events were a previous
infection (38%), usually an upper respiratory tract infection, and/or drug intake
(18.5%) shortly before the onset of the vasculitis. At disease onset the most
common manifestations were skin lesions (55.9%), nephropathy (24%),
gastrointestinal involvement (13.7%), joint symptoms (9.1%), and fever (6.2%).
Cutaneous involvement occurring in all patients, mainly purpuric skin lesion, was
the most common manifestation when the vasculitis was fully established, followed
by gastrointestinal (64.5%), joint (63.1%), and renal involvement (41.2%). The
main laboratory findings were leukocytosis (36.7%), anemia (8.9%), and increased
serum IgA levels (31.7%). The most frequent therapies used were corticosteroids
(35%), nonsteroidal antiinflammatory drugs (14%), and cytotoxic agents (5%).
After a median follow-up of 12 months (IQR, 2-38 mo), complete recovery was
observed in most cases (n = 346; 83.2%), while persistent, usually mild,
nephropathy was observed in only 32 (7.7%) cases. Relapses were observed in
almost a third of patients (n = 133; 31.9%).In conclusion, although HSP is a
typical vasculitis affecting children and young people, it is not uncommon in
adults. The prognosis is favorable in most cases, depending largely on renal
involvement.