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10.1097/MD.0000000000000105

http://scihub22266oqcxt.onion/10.1097/MD.0000000000000105
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C4616294!4616294 !25319439
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suck abstract from ncbi


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pmid25319439
      Medicine+(Baltimore) 2014 ; 93 (18 ): e105
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  • Listeria monocytogenes-associated biliary tract infections: a study of 12 consecutive cases and review #MMPMID25319439
  • Charlier C ; Fevre C ; Travier L ; Cazenave B ; Bracq-Dieye H ; Podevin J ; Assomany D ; Guilbert L ; Bossard C ; Carpentier F ; Cales V ; Leclercq A ; Lecuit M
  • Medicine (Baltimore) 2014[Oct]; 93 (18 ): e105 PMID25319439 show ga
  • At present, little is known regarding Listeria monocytogenes-associated biliary tract infection, a rare form of listeriosis.In this article, we will study 12 culture-proven cases reported to the French National Reference Center for Listeria from 1996 to 2013 and review the 8 previously published cases.Twenty cases were studied: 17 cholecystitis, 2 cholangitis, and 1 biliary cyst infection. Half were men with a median age of 69 years (32-85). Comorbidities were present in 80%, including cirrhosis, rheumatoid arthritis, and diabetes. Five patients received immunosuppressive therapy, including corticosteroids and anti-tumor necrosis factor biotherapies. Half were afebrile. Blood cultures were positive in 60% (3/5). Gallbladder histological lesions were analyzed in 3 patients and evidenced acute, chronic, or necrotic exacerbation of chronic infection. Genoserogroup of the 12 available strains were IVb (n=6), IIb (n=5), and IIa (n=1). Their survival in the bile was not enhanced when compared with isolates from other listeriosis cases. Adverse outcome was reported in 33% (5/15): 3 deaths, 1 recurrence; 75% of the patients with adverse outcome received inadequate antimicrobial therapy (P=0.033).Biliary tract listeriosis is a severe infection associated with high mortality in patients not treated with appropriate therapy. This study provides medical relevance to in vitro and animal studies that had shown Listeria monocytogenes ability to survive in bile and induce overt biliary infections.
  • |Abdominal Pain/epidemiology/microbiology [MESH]
  • |Adult [MESH]
  • |Aged [MESH]
  • |Aged, 80 and over [MESH]
  • |Anti-Bacterial Agents/therapeutic use [MESH]
  • |Bacteremia/diagnosis/drug therapy/epidemiology [MESH]
  • |Biliary Tract Diseases/drug therapy/epidemiology/*microbiology [MESH]
  • |Cholangitis/drug therapy/epidemiology/*microbiology [MESH]
  • |Cholecystectomy/statistics & numerical data [MESH]
  • |Cholecystitis/drug therapy/epidemiology/*microbiology [MESH]
  • |Cholecystolithiasis/epidemiology [MESH]
  • |Comorbidity [MESH]
  • |Cysts/drug therapy/epidemiology/*microbiology [MESH]
  • |Drug Resistance, Bacterial [MESH]
  • |Female [MESH]
  • |Fever/epidemiology/microbiology [MESH]
  • |France/epidemiology [MESH]
  • |Gallbladder Diseases/epidemiology/microbiology [MESH]
  • |Humans [MESH]
  • |Immunosuppressive Agents/adverse effects [MESH]
  • |Listeria monocytogenes/genetics [MESH]
  • |Listeriosis/drug therapy/*epidemiology [MESH]
  • |Male [MESH]
  • |Medication Errors [MESH]
  • |Middle Aged [MESH]
  • |Necrosis [MESH]
  • |Penicillins/therapeutic use [MESH]
  • |Population Surveillance [MESH]


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