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10.1038/srep15379 http://scihub22266oqcxt.onion/10.1038/srep15379 C4615983!4615983 !26493292     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26493292 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 15379 Nephropedia Template TP {{tp|p=26493292 |t=2015. Phosphatidic Acid (PA) can Displace PPAR?/LXR? Binding to The EGFR Promoter Causing its Transrepression in Luminal Cancer Cells |pdf=|usr=}}{{26493292 }} gab.com Text Phosphatidic Acid (PA) can Displace PPAR /LXR Binding to The EGFR Promoter Causing its Transrepression in Luminal Cancer Cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26493292 #FOAvip The expression of the epidermal growth factor receptor (EGFR) is highly regulated in normal cells, whereas some cancer cells have high constitutive levels. Understanding naturally-occurring ways of downregulating EGFR in cancer cells was investigated. Phosphatidic acid (PA) or Nuclear Receptors (NR) PPAR?/RXR?/LXR?, enhance EGFR expression, mediated by the promoter region -856(A) to -226(T). Unexpectedly, the combination of NRs and PA caused repression. PA induces a conformational change in the nuclear receptor PPAR? (increase of alpha-helices at the expense of decreasing beta-sheets), as evidenced by circular dichroism. This represses the naturally-enhancing capability of PPAR? on EGFR transcription. PPAR?-overexpressing cells in the presence of PA > 300 nM or the enzyme that produces it, phospholipase D (PLD), downregulate EGFR expression. The reasons are two-fold. First, PA displaces PPAR? binding to the EGFR promoter at those concentrations. Second, NR heterodimer-dependent promoter activity is weakened in the presence of PA in vivo. Since other genes considered (?-catenin, cyclin D3, PLD2 and ACOX-1) are also downregulated with a PA +?PPAR? combination, the transrepression appears to be a global phenomenon. Lastly, the reported effect is greater in MCF-7 than in MDA-MB-231 breast cancer cells, which could provide a novel basis for regulating excessive expression of EGFR in luminal cancer cells. Twit Text FOAVip Phosphatidic Acid (PA) can Displace PPAR /LXR Binding to The EGFR Promoter Causing its Transrepression in Luminal Cancer Cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26493292 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26493292 #FOAvip English Wikipedia <ref>{{Cite pmid|26493292 }}</ref> Phosphatidic Acid (PA) can Displace PPAR?/LXR? Binding to The EGFR Promoter Causing its Transrepression in Luminal Cancer Cells #MMPMID26493292 Mahankali M ; Farkaly T ; Bedi S ; Hostetler HA ; Gomez-Cambronero J Sci Rep 2015[Oct]; 5 (ä): 15379 PMID26493292 show ga The expression of the epidermal growth factor receptor (EGFR) is highly regulated in normal cells, whereas some cancer cells have high constitutive levels. Understanding naturally-occurring ways of downregulating EGFR in cancer cells was investigated. Phosphatidic acid (PA) or Nuclear Receptors (NR) PPAR?/RXR?/LXR?, enhance EGFR expression, mediated by the promoter region -856(A) to -226(T). Unexpectedly, the combination of NRs and PA caused repression. PA induces a conformational change in the nuclear receptor PPAR? (increase of alpha-helices at the expense of decreasing beta-sheets), as evidenced by circular dichroism. This represses the naturally-enhancing capability of PPAR? on EGFR transcription. PPAR?-overexpressing cells in the presence of PA > 300 nM or the enzyme that produces it, phospholipase D (PLD), downregulate EGFR expression. The reasons are two-fold. First, PA displaces PPAR? binding to the EGFR promoter at those concentrations. Second, NR heterodimer-dependent promoter activity is weakened in the presence of PA in vivo. Since other genes considered (?-catenin, cyclin D3, PLD2 and ACOX-1) are also downregulated with a PA +?PPAR? combination, the transrepression appears to be a global phenomenon. Lastly, the reported effect is greater in MCF-7 than in MDA-MB-231 breast cancer cells, which could provide a novel basis for regulating excessive expression of EGFR in luminal cancer cells. |*Promoter Regions, Genetic [MESH] |Base Sequence [MESH] |Breast Neoplasms/metabolism/pathology [MESH] |Cell Line, Tumor [MESH] |Circular Dichroism [MESH] |DNA [MESH] |ErbB Receptors/*genetics [MESH] |Female [MESH] |Humans [MESH] |Liver X Receptors [MESH] |Molecular Sequence Data [MESH] |Orphan Nuclear Receptors/*metabolism [MESH] |PPAR alpha/*metabolism [MESH]Phosphatidic Acid (PA) can Displace PPAR?/LXR? Binding to The EGFR Pro(epmc).pdf DeepDyve Pubget Overpricing