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10.1080/15476286.2015.1017238 http://scihub22266oqcxt.onion/10.1080/15476286.2015.1017238 C4615785!4615785!25826657     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       RNA+Biol 2015 ; 12 (3): 238-47 Nephropedia Template TP {{tp|p=25826657|t=2015. Unveiling the principle of microRNA-mediated redundancy in cellular pathway regulation |pdf=|usr=}}{{25826657}} gab.com Text Unveiling the principle of microRNA-mediated redundancy in cellular pathway regulation JO: RNA Biol http://www.kidney.de/pget.php?&tw=1&pmid=25826657 #FOAvip Understanding the multifaceted nature of microRNA (miRNA) function in mammalian cells is still a challenge. Commonly accepted principles of cooperativity and multiplicity of miRNA function imply that individual mRNAs can be targeted by several miRNAs whereas a single miRNA may concomitantly regulate a subset of different genes. However, there is a paucity of information whether multiple miRNAs regulate critical cellular events and thereby acting redundantly. To gain insight into this notion, we conducted an unbiased high-content miRNA screen by individually introducing 1139 miRNA mimics into Chinese hamster ovary (CHO) cells. We discovered that 66% of all miRNAs significantly impacted on proliferation, protein expression, apoptosis and necrosis. In summary, we provide evidence for a substantial degree of redundancy among miRNAs to maintain cellular homeostasis. Twit Text FOAVip Unveiling the principle of microRNA-mediated redundancy in cellular pathway regulation ????RNA Biol http://www.kidney.de/pget.php?&tw=1&pmid=25826657 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25826657 #FOAvip English Wikipedia <ref>{{Cite pmid|25826657}}</ref> Unveiling the principle of microRNA-mediated redundancy in cellular pathway regulation #MMPMID25826657 Fischer S; Handrick R; Aschrafi A; Otte K RNA Biol 2015[Mar]; 12 (3): 238-47 PMID25826657show ga Understanding the multifaceted nature of microRNA (miRNA) function in mammalian cells is still a challenge. Commonly accepted principles of cooperativity and multiplicity of miRNA function imply that individual mRNAs can be targeted by several miRNAs whereas a single miRNA may concomitantly regulate a subset of different genes. However, there is a paucity of information whether multiple miRNAs regulate critical cellular events and thereby acting redundantly. To gain insight into this notion, we conducted an unbiased high-content miRNA screen by individually introducing 1139 miRNA mimics into Chinese hamster ovary (CHO) cells. We discovered that 66% of all miRNAs significantly impacted on proliferation, protein expression, apoptosis and necrosis. In summary, we provide evidence for a substantial degree of redundancy among miRNAs to maintain cellular homeostasis. äUnveiling the principle of microRNA-mediated redundancy in cellular pa(epmc).pdf DeepDyve Pubget Overpricing