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10.1080/19491034.2015.1081324

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suck abstract from ncbi


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pmid26325491
      Nucleus 2015 ; 6 (4 ): 273-8
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  • Histone hyperacetylation and exon skipping: a calcium-mediated dynamic regulation in cardiomyocytes #MMPMID26325491
  • Sharma A ; Nguyen H ; Cai L ; Lou H
  • Nucleus 2015[]; 6 (4 ): 273-8 PMID26325491 show ga
  • In contrast to cell type-specific pre-mRNA alternative splicing, mechanisms controlling activity-dependent alternative splicing is under-studied and not well understood. In a recent study, we conducted a comprehensive analysis of calcium-mediated mechanism that regulates alternative exon skipping in mouse cardiomyocytes. Our results reveal a strong link between histone hyperacetylation and skipping of cassette exons, and provide support to the kinetic coupling model of the epigenetic regulation of alternative splicing at the chromatin level.
  • |*Exons [MESH]
  • |Acetylation [MESH]
  • |Alternative Splicing [MESH]
  • |Animals [MESH]
  • |Calcium/*metabolism [MESH]
  • |Chromatin/genetics [MESH]
  • |Epigenesis, Genetic [MESH]
  • |Histones/*metabolism [MESH]
  • |Mice [MESH]
  • |Models, Genetic [MESH]
  • |Myocytes, Cardiac/*metabolism [MESH]
  • |Signal Transduction [MESH]


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