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2015 ; 6
(4
): 273-8
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Histone hyperacetylation and exon skipping: a calcium-mediated dynamic regulation
in cardiomyocytes
#MMPMID26325491
Sharma A
; Nguyen H
; Cai L
; Lou H
Nucleus
2015[]; 6
(4
): 273-8
PMID26325491
show ga
In contrast to cell type-specific pre-mRNA alternative splicing, mechanisms
controlling activity-dependent alternative splicing is under-studied and not well
understood. In a recent study, we conducted a comprehensive analysis of
calcium-mediated mechanism that regulates alternative exon skipping in mouse
cardiomyocytes. Our results reveal a strong link between histone hyperacetylation
and skipping of cassette exons, and provide support to the kinetic coupling model
of the epigenetic regulation of alternative splicing at the chromatin level.