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2005 ; 11
(30
): 4715-20
Nephropedia Template TP
gab.com Text
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English Wikipedia
Implications of anti-parietal cell antibodies and anti-Helicobacter pylori
antibodies in histological gastritis and patient outcome
#MMPMID16094716
Lo CC
; Hsu PI
; Lo GH
; Lai KH
; Tseng HH
; Lin CK
; Chan HH
; Tsai WL
; Chen WC
; Peng NJ
World J Gastroenterol
2005[Aug]; 11
(30
): 4715-20
PMID16094716
show ga
AIM: To develop a serum or histological marker for early discovery of gastric
atrophy or intestinal metaplasia. METHODS: This study enrolled 44 patients with
gastric adenocarcinoma, 52 patients with duodenal ulcer, 14 patients with gastric
ulcer and 42 consecutive healthy adults as controls. Each patient received an
endoscopy and five biopsy samples were obtained. The degrees of histological
parameters of gastritis were categorized following the Updated Sydney System.
Anti-parietal cell antibodies (APCA) and anti-Helicobacter pylori (H pylori)
antibodies (AHPA) were analyzed by immunoassays. H pylori infection was diagnosed
by rapid urease test and histological examination. RESULTS: Patients with gastric
cancer and gastric ulcer are significantly older than healthy subjects, while
also displaying higher frequency of APCA than healthy controls. Patients with
positive APCA showed higher scores in gastric atrophy and intestinal metaplasia
of corpus than patients with negative APCA. Patients with positive AHPA had
higher scores in gastric atrophy, intestinal metaplasia, and gastric inflammation
of antrum than those patients with negative AHPA. Elderly patients had greater
prevalence rates of APCA. Following multivariant logistic regression analysis,
the only significant risk factor for antral atrophy is positive AHPA, while that
for corpus atrophy is positive APCA. CONCLUSION: The existence of positive APCA
correlates with glandular atrophy in corpus and the presence of positive AHPA
correlates with glandular atrophy in antrum. The existence of serum APCA and AHPA
betokens glandular atrophy and requires further examination for gastric cancer.