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10.1016/j.juro.2015.04.117 http://scihub22266oqcxt.onion/10.1016/j.juro.2015.04.117 C4615387!4615387 !26032139     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26032139 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Urol 2015 ; 194 (5 ): 1420-4 Nephropedia Template TP {{tp|p=26032139 |t=2015. Histology of Testicular Biopsies Obtained for Experimental Fertility Preservation Protocol in Boys with Cancer |pdf=|usr=}}{{26032139 }} gab.com Text Histology of Testicular Biopsies Obtained for Experimental Fertility Preservation Protocol in Boys with Cancer JO: J Urol http://www.kidney.de/pget.php?&tw=1&pmid=26032139 #FOAvip PURPOSE: Cryopreservation of testicular tissue with subsequent reimplantation after therapy has the potential to preserve fertility for prepubertal boys with cancer. We present the histology and feasibility of testicular tissue procurement for this novel approach. MATERIALS AND METHODS: We performed a prospective cohort study of boys at significant risk for treatment associated gonadotoxicity who were eligible for an experimental research protocol between 2008 and 2011. Open testicular biopsy was performed while the patients were anesthetized for another treatment related procedure. Half of the specimen was reserved for cryopreservation, while the other half was used for research purposes. Semithin sections of the biopsy specimens were evaluated for histological features and compared to age adjusted reference values. RESULTS: A total of 34 boys underwent biopsy between March 2008 and October 2011. Of the patients 29 had solid tumors and 5 underwent hematopoietic stem cell transplantation for benign disease. A total of 27 patients had adequate tissue for histological analysis. Median patient age was 8.7 years (IQR 2.2 to 11.5). All children had either normal (81.5% of patients) or increased (18.5%) numbers of germ cells per tubule for their age. However, 5 of 26 patients (19%) older than 6 months had no evidence of adult dark spermatogonia and 9 of 16 (56%) older than 6 years had no evidence of primary spermatocytes on biopsy, which would be expected based on age norms. These findings are suggestive of abnormal germ cell maturation. CONCLUSIONS: The preliminary histological findings of abnormal spermatogenesis maturation in the testes of prepubertal boys with cancer warrants further investigation. Twit Text FOAVip Histology of Testicular Biopsies Obtained for Experimental Fertility Preservation Protocol in Boys with Cancer ????J Urol http://www.kidney.de/pget.php?&tw=1&pmid=26032139 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26032139 #FOAvip English Wikipedia <ref>{{Cite pmid|26032139 }}</ref> Histology of Testicular Biopsies Obtained for Experimental Fertility Preservation Protocol in Boys with Cancer #MMPMID26032139 Pietzak EJ 3rd ; Tasian GE ; Tasian SK ; Brinster RL ; Carlson C ; Ginsberg JP ; Kolon TF J Urol 2015[Nov]; 194 (5 ): 1420-4 PMID26032139 show ga PURPOSE: Cryopreservation of testicular tissue with subsequent reimplantation after therapy has the potential to preserve fertility for prepubertal boys with cancer. We present the histology and feasibility of testicular tissue procurement for this novel approach. MATERIALS AND METHODS: We performed a prospective cohort study of boys at significant risk for treatment associated gonadotoxicity who were eligible for an experimental research protocol between 2008 and 2011. Open testicular biopsy was performed while the patients were anesthetized for another treatment related procedure. Half of the specimen was reserved for cryopreservation, while the other half was used for research purposes. Semithin sections of the biopsy specimens were evaluated for histological features and compared to age adjusted reference values. RESULTS: A total of 34 boys underwent biopsy between March 2008 and October 2011. Of the patients 29 had solid tumors and 5 underwent hematopoietic stem cell transplantation for benign disease. A total of 27 patients had adequate tissue for histological analysis. Median patient age was 8.7 years (IQR 2.2 to 11.5). All children had either normal (81.5% of patients) or increased (18.5%) numbers of germ cells per tubule for their age. However, 5 of 26 patients (19%) older than 6 months had no evidence of adult dark spermatogonia and 9 of 16 (56%) older than 6 years had no evidence of primary spermatocytes on biopsy, which would be expected based on age norms. These findings are suggestive of abnormal germ cell maturation. CONCLUSIONS: The preliminary histological findings of abnormal spermatogenesis maturation in the testes of prepubertal boys with cancer warrants further investigation. |*Fertility [MESH] |Adolescent [MESH] |Biopsy [MESH] |Cell Transplantation/*methods [MESH] |Child [MESH] |Child, Preschool [MESH] |Cryopreservation [MESH] |Fertility Preservation/*methods [MESH] |Follow-Up Studies [MESH] |Humans [MESH] |Infertility, Male/diagnosis/pathology/*prevention & control [MESH] |Male [MESH] |Neoplasms/*diagnosis/metabolism/therapy [MESH] |Prospective Studies [MESH] |Sperm Count [MESH] |Spermatogenesis [MESH] |Testis/*pathology [MESH]Histology of Testicular Biopsies Obtained for Experimental Fertility P(epmc).pdf DeepDyve Pubget Overpricing