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10.4161/19491034.2014.990864 http://scihub22266oqcxt.onion/10.4161/19491034.2014.990864 C4615376!4615376!25485975     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nucleus 2014 ; 5 (6): 636-42 Nephropedia Template TP {{tp|p=25485975|t=2014. A mRNA and Cognate MicroRNAs Localize in the Nucleolus |pdf=|usr=}}{{25485975}} gab.com Text A mRNA and Cognate MicroRNAs Localize in the Nucleolus JO: Nucleus http://www.kidney.de/pget.php?&tw=1&pmid=25485975 #FOAvip We previously discovered that a set of 5 microRNAs are concentrated in the nucleolus of rat myoblasts. We now report that several mRNAs are also localized in the nucleoli of these cells as determined by microarray analysis of RNA from purified nucleoli. Among the most abundant of these nucleolus-localized mRNAs is that encoding insulin-like growth factor 2 (IGF2), a regulator of myoblast proliferation and differentiation. The presence of IGF2 mRNA in nucleoli was confirmed by fluorescence in situ hybridization, and RT-PCR experiments demonstrated that these nucleolar transcripts are spliced, thus arriving from the nucleoplasm. Bioinformatics analysis predicted canonically structured, highly thermodynamically stable interactions between IGF2 mRNA and all 5 of the nucleolus-localized microRNAs. These results raise the possibility that the nucleolus is a staging site for setting up particular mRNA-microRNA interactions prior to export to the cytoplasm. Twit Text FOAVip A mRNA and Cognate MicroRNAs Localize in the Nucleolus ????Nucleus http://www.kidney.de/pget.php?&tw=1&pmid=25485975 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25485975 #FOAvip English Wikipedia <ref>{{Cite pmid|25485975}}</ref> A mRNA and Cognate MicroRNAs Localize in the Nucleolus #MMPMID25485975 Reyes-Gutierrez P; Ritland Politz JC; Pederson T Nucleus 2014[]; 5 (6): 636-42 PMID25485975show ga We previously discovered that a set of 5 microRNAs are concentrated in the nucleolus of rat myoblasts. We now report that several mRNAs are also localized in the nucleoli of these cells as determined by microarray analysis of RNA from purified nucleoli. Among the most abundant of these nucleolus-localized mRNAs is that encoding insulin-like growth factor 2 (IGF2), a regulator of myoblast proliferation and differentiation. The presence of IGF2 mRNA in nucleoli was confirmed by fluorescence in situ hybridization, and RT-PCR experiments demonstrated that these nucleolar transcripts are spliced, thus arriving from the nucleoplasm. Bioinformatics analysis predicted canonically structured, highly thermodynamically stable interactions between IGF2 mRNA and all 5 of the nucleolus-localized microRNAs. These results raise the possibility that the nucleolus is a staging site for setting up particular mRNA-microRNA interactions prior to export to the cytoplasm. äA mRNA and Cognate MicroRNAs Localize in the Nucleolus (epmc).pdf DeepDyve Pubget Overpricing