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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nucleus 2015 ; 6 (2): 118-22 Nephropedia Template TP
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Roles of chromatin insulators in the formation of long-range contacts #MMPMID25781057
Le Gall A; Valeri A; Nollmann M
Nucleus 2015[]; 6 (2): 118-22 PMID25781057show ga
Chromatin insulators are factors involved in higher-order, genome-wide organization of chromatin, and play key roles in regulating transcriptional programs. In this review, we discuss recent studies on the diverse composition of insulator complexes, and on the mechanism by which they establish long-range DNA interactions. Particularly, we describe new biophysical methods that allow for the study of the composition of large molecular complexes, and for defining the factors potentially required to establish long-range DNA contacts.