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Angiogenesis in Glaucoma Filtration Surgery and Neovascular Glaucoma-A Review #MMPMID25980779
Kim M; Lee C; Payne R; Yue BY; Chang JH; Ying H
Surv Ophthalmol 2015[Nov]; 60 (6): 524-35 PMID25980779show ga
Angiogenesis may pose a clinical challenge in glaucoma, for example during the wound healing phase after glaucoma filtration surgery and in a severe form of secondary glaucoma called neovascular glaucoma (NVG). Up regulation of vascular endothelial growth factor (VEGF), a key mediator of angiogenesis, occurs in eyes that have undergone glaucoma filtration surgery, as well as those with NVG. This has led to studies investigating the ability of anti-VEGF therapy to improve outcomes, and we examine their findings with respect to the safety and efficacy of anti-VEGF agents, mainly bevacizumab and ranibizumab, in eyes that have undergone glaucoma filtration surgery or have NVG. Combining conventional therapies?such as anti-metabolites after filtration surgery and panretinal photocoagulation in NVG?and anti-VEGF drugs may achieve a synergetic effect, although further studies are required to evaluate the long-term efficacy of combination treatments.