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10.4161/19491034.2014.970105 http://scihub22266oqcxt.onion/10.4161/19491034.2014.970105 C4615202!4615202 !25482068     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25482068 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nucleus 2014 ; 5 (6 ): 527-41 Nephropedia Template TP {{tp|p=25482068 |t=2014. Cellular stress induces Bax-regulated nuclear bubble budding and rupture followed by nuclear protein release |pdf=|usr=}}{{25482068 }} gab.com Text Cellular stress induces Bax-regulated nuclear bubble budding and rupture followed by nuclear protein release JO: Nucleus http://www.kidney.de/pget.php?&tw=1&pmid=25482068 #FOAvip Cellular stress triggers many pathways including nuclear protein redistribution. We previously discovered that this process is regulated by Bax but the underlying mechanism has not yet been studied. Here we define this mechanism by showing that apoptotic stimuli cause Bax-regulated disturbances in lamin A/C and nuclear envelope (NE)-associated proteins which results in the generation and subsequent rupture of nuclear protein-containing bubbles. The bubbles do not contain DNA and are encapsulated by impaired nuclear pore-depleted NE. Stress-induced generation and rupture of nuclear bubbles ultimately leads to the discharge of nuclear proteins into the cytoplasm. This process precedes morphological changes of apoptosis and occurs independently of caspases. Rescue experiments revealed that this Bax effect is non-canonical, i.e. it requires the BH3 domain and ?-helices 5 and 6 but it is not inhibited by Bcl(-)xL. Targeting Bax to the NE by the Klarsicht/ANC-1/Syne-1 homology (KASH) domain effectively triggers the generation and rupture of nuclear bubbles. Overall, our findings provide evidence for a novel stress-response, which is regulated by a non-canonical action of Bax on the NE. Twit Text FOAVip Cellular stress induces Bax-regulated nuclear bubble budding and rupture followed by nuclear protein release ????Nucleus http://www.kidney.de/pget.php?&tw=1&pmid=25482068 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25482068 #FOAvip English Wikipedia <ref>{{Cite pmid|25482068 }}</ref> Cellular stress induces Bax-regulated nuclear bubble budding and rupture followed by nuclear protein release #MMPMID25482068 Lindenboim L ; Sasson T ; Worman HJ ; Borner C ; Stein R Nucleus 2014[]; 5 (6 ): 527-41 PMID25482068 show ga Cellular stress triggers many pathways including nuclear protein redistribution. We previously discovered that this process is regulated by Bax but the underlying mechanism has not yet been studied. Here we define this mechanism by showing that apoptotic stimuli cause Bax-regulated disturbances in lamin A/C and nuclear envelope (NE)-associated proteins which results in the generation and subsequent rupture of nuclear protein-containing bubbles. The bubbles do not contain DNA and are encapsulated by impaired nuclear pore-depleted NE. Stress-induced generation and rupture of nuclear bubbles ultimately leads to the discharge of nuclear proteins into the cytoplasm. This process precedes morphological changes of apoptosis and occurs independently of caspases. Rescue experiments revealed that this Bax effect is non-canonical, i.e. it requires the BH3 domain and ?-helices 5 and 6 but it is not inhibited by Bcl(-)xL. Targeting Bax to the NE by the Klarsicht/ANC-1/Syne-1 homology (KASH) domain effectively triggers the generation and rupture of nuclear bubbles. Overall, our findings provide evidence for a novel stress-response, which is regulated by a non-canonical action of Bax on the NE. |Animals [MESH] |Apoptosis/genetics [MESH] |Cell Nucleus/*genetics/metabolism [MESH] |Cell Tracking [MESH] |Embryo, Mammalian [MESH] |Fibroblasts [MESH] |Gene Expression Regulation, Developmental [MESH] |Lamin Type A/*genetics/metabolism [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Nuclear Envelope/genetics [MESH] |Nuclear Proteins/biosynthesis [MESH] |Nucleolin [MESH] |Phosphoproteins/metabolism [MESH] |RNA-Binding Proteins/metabolism [MESH] |Stress, Physiological/*genetics [MESH]Cellular stress induces Bax-regulated nuclear bubble budding and ruptu(epmc).pdf DeepDyve Pubget Overpricing