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10.1080/15384101.2015.1044174 http://scihub22266oqcxt.onion/10.1080/15384101.2015.1044174 C4614552!4614552!25946202     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Cycle 2015 ; 14 (14): 2323-32 Nephropedia Template TP {{tp|p=25946202|t=2015. Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure |pdf=|usr=}}{{25946202}} gab.com Text Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure JO: Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=25946202 #FOAvip The tumor suppressor, PTEN, is one of the most commonly mutated genes in cancer. Recently, PTEN has been shown to localize in the nucleus and is required to maintain genomic stability. Here, we show that nuclear PTEN, independent of its phosphatase activity, is essential for maintaining heterochromatin structure. Depletion of PTEN leads to loss of heterochromatic foci, decreased chromatin compaction, overexpression of heterochromatic genes, and reduced protein stability of heterochromatin protein 1 ?. We found that the C-terminus of PTEN is required to maintain heterochromatin structure. Additionally, cancer-associated PTEN mutants lost their tumor-suppressor function when their heterochromatin structure was compromised. We propose that this novel role of PTEN accounts for its function in guarding genomic stability and suppressing tumor development. Twit Text FOAVip Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure ????Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=25946202 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25946202 #FOAvip English Wikipedia <ref>{{Cite pmid|25946202}}</ref> Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure #MMPMID25946202 Gong L; Govan JM; Evans EB; Dai H; Wang E; Lee SW; Lin HK; Lazar AJ; Mills GB; Lin SY Cell Cycle 2015[Jul]; 14 (14): 2323-32 PMID25946202show ga The tumor suppressor, PTEN, is one of the most commonly mutated genes in cancer. Recently, PTEN has been shown to localize in the nucleus and is required to maintain genomic stability. Here, we show that nuclear PTEN, independent of its phosphatase activity, is essential for maintaining heterochromatin structure. Depletion of PTEN leads to loss of heterochromatic foci, decreased chromatin compaction, overexpression of heterochromatic genes, and reduced protein stability of heterochromatin protein 1 ?. We found that the C-terminus of PTEN is required to maintain heterochromatin structure. Additionally, cancer-associated PTEN mutants lost their tumor-suppressor function when their heterochromatin structure was compromised. We propose that this novel role of PTEN accounts for its function in guarding genomic stability and suppressing tumor development. äNuclear PTEN tumor-suppressor functions through maintaining heterochro(epmc).pdf DeepDyve Pubget Overpricing