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10.1080/15384101.2015.1026513 http://scihub22266oqcxt.onion/10.1080/15384101.2015.1026513 C4614519!4614519 !25785996     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25785996 &cmd=llinks): Failed to open stream: HTTP request failed! 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Cyclin A1 regulates the interactions between mouse haematopoietic stem and progenitor cells and their niches |pdf=|usr=}}{{25785996 }} gab.com Text Cyclin A1 regulates the interactions between mouse haematopoietic stem and progenitor cells and their niches JO: Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=25785996 #FOAvip It remains poorly understood how the haematopoietic stem/progenitor cells (HSPC) are attracted to their niches and the functional consequences of such interaction. In the present study, we show that the cell cycle regulator cyclin A1 in association with vascular endothelial growth factor receptor 1 (VEGFR1), is required for HSPC and their niches to maintain their function and proper interaction. In the absence of cyclin A1, the HSPC in the BM are increased in their frequency and display an increased migratory and homing ability. Concomitantly, the ability of the endosteal and central BM niche zones to attract and home the wild-type HSPC is significantly reduced in cyclin A1-null mice as compared to the wild-type controls. The impaired proliferation and homing of HSPC in the BM of cyclin A1-null mice are attributed to the increased density of microvessels in the endosteal and central BM niche zones, which is associated with the increased VEGFR1 expression. Thus, modulation of cyclin A1 and VEGFR1 in HSPC and their niches may provide new insights into therapeutic approaches. Twit Text FOAVip Cyclin A1 regulates the interactions between mouse haematopoietic stem and progenitor cells and their niches ????Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=25785996 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25785996 #FOAvip English Wikipedia <ref>{{Cite pmid|25785996 }}</ref> Cyclin A1 regulates the interactions between mouse haematopoietic stem and progenitor cells and their niches #MMPMID25785996 Miftakhova R ; Hedblom A ; Batkiewicz L ; Anagnosaki L ; Zhang Y ; Sjölander A ; Wingren AG ; Wolgemuth DJ ; Persson JL Cell Cycle 2015[]; 14 (12 ): 1948-60 PMID25785996 show ga It remains poorly understood how the haematopoietic stem/progenitor cells (HSPC) are attracted to their niches and the functional consequences of such interaction. In the present study, we show that the cell cycle regulator cyclin A1 in association with vascular endothelial growth factor receptor 1 (VEGFR1), is required for HSPC and their niches to maintain their function and proper interaction. In the absence of cyclin A1, the HSPC in the BM are increased in their frequency and display an increased migratory and homing ability. Concomitantly, the ability of the endosteal and central BM niche zones to attract and home the wild-type HSPC is significantly reduced in cyclin A1-null mice as compared to the wild-type controls. The impaired proliferation and homing of HSPC in the BM of cyclin A1-null mice are attributed to the increased density of microvessels in the endosteal and central BM niche zones, which is associated with the increased VEGFR1 expression. Thus, modulation of cyclin A1 and VEGFR1 in HSPC and their niches may provide new insights into therapeutic approaches. |Animals [MESH] |Bone Marrow Transplantation [MESH] |Cell Membrane/metabolism [MESH] |Cell Movement [MESH] |Cell Proliferation [MESH] |Cell Separation [MESH] |Cyclin A1/*metabolism [MESH] |Female [MESH] |Fibronectins/metabolism [MESH] |Genotype [MESH] |Hematopoietic Stem Cells/*cytology [MESH] |Homozygote [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |Stem Cell Niche/*physiology [MESH]Cyclin A1 regulates the interactions between mouse haematopoietic stem(epmc).pdf DeepDyve Pubget Overpricing