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10.1098/rsif.2015.0597 http://scihub22266oqcxt.onion/10.1098/rsif.2015.0597 C4614471!4614471!26333812     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+R+Soc+Interface 2015 ; 12 (110): ä Nephropedia Template TP {{tp|p=26333812|t=2015. Information processing by simple molecular motifs and susceptibility to noise |pdf=|usr=}}{{26333812}} gab.com Text Information processing by simple molecular motifs and susceptibility to noise JO: J R Soc Interface http://www.kidney.de/pget.php?&tw=1&pmid=26333812 #FOAvip Biological organisms rely on their ability to sense and respond appropriately to their environment. The molecular mechanisms that facilitate these essential processes are however subject to a range of random effects and stochastic processes, which jointly affect the reliability of information transmission between receptors and, for example, the physiological downstream response. Information is mathematically defined in terms of the entropy; and the extent of information flowing across an information channel or signalling system is typically measured by the ?mutual information?, or the reduction in the uncertainty about the output once the input signal is known. Here, we quantify how extrinsic and intrinsic noise affects the transmission of simple signals along simple motifs of molecular interaction networks. Even for very simple systems, the effects of the different sources of variability alone and in combination can give rise to bewildering complexity. In particular, extrinsic variability is apt to generate ?apparent? information that can, in extreme cases, mask the actual information that for a single system would flow between the different molecular components making up cellular signalling pathways. We show how this artificial inflation in apparent information arises and how the effects of different types of noise alone and in combination can be understood. Twit Text FOAVip Information processing by simple molecular motifs and susceptibility to noise ????J R Soc Interface http://www.kidney.de/pget.php?&tw=1&pmid=26333812 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26333812 #FOAvip English Wikipedia <ref>{{Cite pmid|26333812}}</ref> Information processing by simple molecular motifs and susceptibility to noise #MMPMID26333812 Mc Mahon SS; Lenive O; Filippi S; Stumpf MPH J R Soc Interface 2015[Sep]; 12 (110): ä PMID26333812show ga Biological organisms rely on their ability to sense and respond appropriately to their environment. The molecular mechanisms that facilitate these essential processes are however subject to a range of random effects and stochastic processes, which jointly affect the reliability of information transmission between receptors and, for example, the physiological downstream response. Information is mathematically defined in terms of the entropy; and the extent of information flowing across an information channel or signalling system is typically measured by the ?mutual information?, or the reduction in the uncertainty about the output once the input signal is known. Here, we quantify how extrinsic and intrinsic noise affects the transmission of simple signals along simple motifs of molecular interaction networks. Even for very simple systems, the effects of the different sources of variability alone and in combination can give rise to bewildering complexity. In particular, extrinsic variability is apt to generate ?apparent? information that can, in extreme cases, mask the actual information that for a single system would flow between the different molecular components making up cellular signalling pathways. We show how this artificial inflation in apparent information arises and how the effects of different types of noise alone and in combination can be understood. äInformation processing by simple molecular motifs and susceptibility t(epmc).pdf DeepDyve Pubget Overpricing