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2015 ; 12
(110
): 0446
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Super or just above average ? Supershedders and the transmission of
Escherichia coli O157:H7 among feedlot cattle
#MMPMID26269231
Spencer SE
; Besser TE
; Cobbold RN
; French NP
J R Soc Interface
2015[Sep]; 12
(110
): 0446
PMID26269231
show ga
Supershedders have been suggested to be major drivers of transmission of
Escherichia coli O157:H7 (E. coli O157:H7) among cattle in feedlot environments,
despite our relatively limited knowledge of the processes that govern periods of
high shedding within an individual animal. In this study, we attempt a
data-driven approach, estimating the key characteristics of high shedding
behaviour, including effects on transmission to other animals, directly from a
study of natural E. coli O157:H7 infection of cattle in a research feedlot, in
order to develop an evidence-based definition of supershedding. In contrast to
the hypothesized role of supershedders, we found that high shedding individuals
only modestly increased the risk of transmission: individuals shedding over 10(3)
cfu g(-1) faeces were estimated to pose a risk of transmission only 2.45 times
greater than those shedding below that level. The data suggested that shedding
above 10(3) cfu g(-1) faeces was the most appropriate definition of supershedding
behaviour and under this definition supershedding was surprisingly common, with
an estimated prevalence of 31.3% in colonized individuals. We found no evidence
that environmental contamination by faeces of shedding cattle contributed to
transmission over timescales longer than 3 days and preliminary evidence that
higher stocking density increased the risk of transmission.
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