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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cancer+Res+Treat 2015 ; 47 (4): 823-33 Nephropedia Template TP
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APE1/Ref-1 as a Serological Biomarker for the Detection of Bladder Cancer #MMPMID25672588
Shin JH; Choi S; Lee YR; Park MS; Na YG; Irani K; Lee SD; Park JB; Kim JM; Lim JS; Jeon BH
Cancer Res Treat 2015[Oct]; 47 (4): 823-33 PMID25672588show ga
Purpose: Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that shows elevated expression in a number of cancers. We attempted to determine whether serum APE1/Ref-1 is elevated in patients with bladder cancer. Materials and Methods: Serum APE1/Ref-1 levels were determined using enzyme-linked immunosorbent assay in serum from patients with bladder cancer who had not received chemotherapy or radiotherapy (n=51) and non-tumor controls (n=55). The area under the receiver operating characteristic area under the curve was applied to determine the correlation between clinical factors and the serum levels of APE1/Ref-1. Results: Serum levels of APE1/Ref-1 in bladder cancer patients were significantly elevated compared to those of the control group (3.548±0.333 ng/100 ?L [n=51] for bladder cancer vs. 1.547±0.319 ng/100 ?L [n=55] for the control group), with a sensitivity and specificity of 93% and 59%, respectively. Serum APE1/Ref-1 levels are associated with tumor stage, grade, muscle invasion, and recurrence. Conclusion: Serum APE1/Ref-1 might be useful as a potential serologic biomarker for bladder cancer.