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10.1080/15384101.2015.1026515 http://scihub22266oqcxt.onion/10.1080/15384101.2015.1026515 C4613855!4613855!25789785     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Cycle 2015 ; 14 (10): 1496-506 Nephropedia Template TP {{tp|p=25789785|t=2015. Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor |pdf=|usr=}}{{25789785}} gab.com Text Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor JO: Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=25789785 #FOAvip The evolutionarily conserved neoplastic tumor suppressor protein, Lethal (2) giant larvae (Lgl), plays roles in cell polarity and tissue growth via regulation of the Hippo pathway. In our recent study, we showed that in the developing Drosophila eye epithelium, depletion of Lgl leads to increased ligand-dependent Notch signaling. lgl mutant tissue also exhibits an accumulation of early endosomes, recycling endosomes, early-multivesicular body markers and acidic vesicles. We showed that elevated Notch signaling in lgl? tissue can be rescued by feeding larvae the vesicle de-acidifying drug chloroquine, revealing that Lgl attenuates Notch signaling by limiting vesicle acidification. Strikingly, chloroquine also rescued the lgl? overgrowth phenotype, suggesting that the Hippo pathway defects were also rescued. In this extraview, we provide additional data on the regulation of Notch signaling and endocytosis by Lgl, and discuss possible mechanisms by which Lgl depletion contributes to signaling pathway defects and tumorigenesis. Twit Text FOAVip Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor ????Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=25789785 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25789785 #FOAvip English Wikipedia <ref>{{Cite pmid|25789785}}</ref> Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor #MMPMID25789785 Portela M; Parsons LM; Grzeschik NA; Richardson HE Cell Cycle 2015[May]; 14 (10): 1496-506 PMID25789785show ga The evolutionarily conserved neoplastic tumor suppressor protein, Lethal (2) giant larvae (Lgl), plays roles in cell polarity and tissue growth via regulation of the Hippo pathway. In our recent study, we showed that in the developing Drosophila eye epithelium, depletion of Lgl leads to increased ligand-dependent Notch signaling. lgl mutant tissue also exhibits an accumulation of early endosomes, recycling endosomes, early-multivesicular body markers and acidic vesicles. We showed that elevated Notch signaling in lgl? tissue can be rescued by feeding larvae the vesicle de-acidifying drug chloroquine, revealing that Lgl attenuates Notch signaling by limiting vesicle acidification. Strikingly, chloroquine also rescued the lgl? overgrowth phenotype, suggesting that the Hippo pathway defects were also rescued. In this extraview, we provide additional data on the regulation of Notch signaling and endocytosis by Lgl, and discuss possible mechanisms by which Lgl depletion contributes to signaling pathway defects and tumorigenesis. äRegulation of Notch signaling and endocytosis by the Lgl neoplastic tu(epmc).pdf DeepDyve Pubget Overpricing