Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1007/s12017-009-8083-0 http://scihub22266oqcxt.onion/10.1007/s12017-009-8083-0 C4613768!4613768!19657747     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuromolecular+Med 2009 ; 11 (4): 252-66 Nephropedia Template TP {{tp|p=19657747|t=2009. Manganese and its Role in Parkinson?s Disease: From Transport to Neuropathology |pdf=|usr=}}{{19657747}} gab.com Text Manganese and its Role in Parkinson s Disease: From Transport to Neuropathology JO: Neuromolecular Med http://www.kidney.de/pget.php?&tw=1&pmid=19657747 #FOAvip The purpose of this review is to highlight recent advances in the neuropathology associated with Mn exposures. We commence with a discussion on occupational manganism and clinical aspects of the disorder. This is followed by novel considerations on Mn transport (see also chapter by Yokel, this volume), advancing new hypotheses on the involvement of several transporters in Mn entry into the brain. This is followed by a brief description of the effects of Mn on neurotransmitter systems that are putative modulators of dopamine (DA) biology (the primary target of Mn neurotoxicity), as well as its effects on mitochondrial dysfunction and disruption of cellular energy metabolism. Next, we discuss inflammatory activation of glia in neuronal injury and how disruption of synaptic transmission and glial-neuronal communication may serve as underlying mechanisms of Mn-induced neurodegeneration commensurate with the cross-talk between glia and neurons. We conclude with a discussion on therapeutic aspects of Mn exposure. Emphasis is directed at treatment modalities and the utility of chelators in attenuating the neurodegenerative sequelae of exposure to Mn. For additional reading on several topics inherent to this review as well as others, the reader may wish to consult Aschner and Dorman (Toxicological Review 25:147?154, 2007) and Bowman et al. (Metals and neurodegeneration, 2009). Twit Text FOAVip Manganese and its Role in Parkinson s Disease: From Transport to Neuropathology ????Neuromolecular Med http://www.kidney.de/pget.php?&tw=1&pmid=19657747 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19657747 #FOAvip English Wikipedia <ref>{{Cite pmid|19657747}}</ref> Manganese and its Role in Parkinson?s Disease: From Transport to Neuropathology #MMPMID19657747 Aschner M; Erikson KM; Hernández EH; Tjalkens R Neuromolecular Med 2009[]; 11 (4): 252-66 PMID19657747show ga The purpose of this review is to highlight recent advances in the neuropathology associated with Mn exposures. We commence with a discussion on occupational manganism and clinical aspects of the disorder. This is followed by novel considerations on Mn transport (see also chapter by Yokel, this volume), advancing new hypotheses on the involvement of several transporters in Mn entry into the brain. This is followed by a brief description of the effects of Mn on neurotransmitter systems that are putative modulators of dopamine (DA) biology (the primary target of Mn neurotoxicity), as well as its effects on mitochondrial dysfunction and disruption of cellular energy metabolism. Next, we discuss inflammatory activation of glia in neuronal injury and how disruption of synaptic transmission and glial-neuronal communication may serve as underlying mechanisms of Mn-induced neurodegeneration commensurate with the cross-talk between glia and neurons. We conclude with a discussion on therapeutic aspects of Mn exposure. Emphasis is directed at treatment modalities and the utility of chelators in attenuating the neurodegenerative sequelae of exposure to Mn. For additional reading on several topics inherent to this review as well as others, the reader may wish to consult Aschner and Dorman (Toxicological Review 25:147?154, 2007) and Bowman et al. (Metals and neurodegeneration, 2009). äManganese and its Role in Parkinson?s Disease: From Transport to Neuro(epmc).pdf DeepDyve Pubget Overpricing