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10.1042/BJ20150382

http://scihub22266oqcxt.onion/10.1042/BJ20150382
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C4613526!4613526!26195824
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suck abstract from ncbi


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pmid26195824      Biochem+J 2015 ; 471 (Pt 1): 25-35
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  • DNA cytosine and methylcytosine deamination by APOBEC3B: enhancing methylcytosine deamination by engineering APOBEC3B #MMPMID26195824
  • Fu Y; Ito F; Zhang G; Fernandez B; Yang H; Chen X
  • Biochem J 2015[Oct]; 471 (Pt 1): 25-35 PMID26195824show ga
  • It is unclear whether both CD1 and CD2 of A3B can deaminate C and mC. We showed that only CD2 is active, and has weak mC deaminating activity. We successfully engineered A3BCD2 to gain over 100-fold higher mC deamination activity.
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