Transition metals activate TFEB in overexpressing cells #MMPMID26251447
Peņa K; Kiselyov K
Biochem J 2015[Aug]; 470 (Pt 1): 65-76 PMID26251447show ga
Exposure of cells to micromolar Cu activates recombinant transcription factor EB (TFEB), leading to expression of the lysosomal network genes. Whereas TFEB overexpression has a cytoprotective effect under moderate Cu exposure, it enhances oxidative stress and mitochondrial damage caused by high levels of Cu.