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10.1042/BST20150049 http://scihub22266oqcxt.onion/10.1042/BST20150049 C4613493!4613493!26551705     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Soc+Trans 2015 ; 43 (4): 639-44 Nephropedia Template TP {{tp|p=26551705|t=2015. Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism |pdf=|usr=}}{{26551705}} gab.com Text Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism JO: Biochem Soc Trans http://www.kidney.de/pget.php?&tw=1&pmid=26551705 #FOAvip Cancer cells adapt their metabolism to their increased needs for energy and substrates for protein, lipid and nucleic acid synthesis. Nuclear erythroid factor 2-like 2 (Nrf2) pathway is usually activated in cancers and has been suggested to promote cancer cell survival mainly by inducing a large battery of cytoprotective genes. This mini review focuses on metabolic pathways, beyond cytoprotection, which can be directly or indirectly regulated by Nrf2 in cancer cells to affect their survival. The pentose phosphate pathway (PPP) is enhanced by Nrf2 in cancers and aids their growth. PPP has also been found to be up-regulated in non-cancer tissues and other pathways, such as de novo lipogenesis, have been found to be repressed after activation of the Nrf2 pathway. The importance of these Nrf2-regulated metabolic pathways in cancer compared with non-cancer state remains to be determined. Last but not least, the importance of context about Nrf2 and cancer is highlighted as the Nrf2 pathway may be activated in cancers but its pharmacological activators are useful in chemoprevention. Twit Text FOAVip Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism ????Biochem Soc Trans http://www.kidney.de/pget.php?&tw=1&pmid=26551705 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26551705 #FOAvip English Wikipedia <ref>{{Cite pmid|26551705}}</ref> Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism #MMPMID26551705 Chartoumpekis D; Wakabayashi N; Kensler T Biochem Soc Trans 2015[Aug]; 43 (4): 639-44 PMID26551705show ga Cancer cells adapt their metabolism to their increased needs for energy and substrates for protein, lipid and nucleic acid synthesis. Nuclear erythroid factor 2-like 2 (Nrf2) pathway is usually activated in cancers and has been suggested to promote cancer cell survival mainly by inducing a large battery of cytoprotective genes. This mini review focuses on metabolic pathways, beyond cytoprotection, which can be directly or indirectly regulated by Nrf2 in cancer cells to affect their survival. The pentose phosphate pathway (PPP) is enhanced by Nrf2 in cancers and aids their growth. PPP has also been found to be up-regulated in non-cancer tissues and other pathways, such as de novo lipogenesis, have been found to be repressed after activation of the Nrf2 pathway. The importance of these Nrf2-regulated metabolic pathways in cancer compared with non-cancer state remains to be determined. Last but not least, the importance of context about Nrf2 and cancer is highlighted as the Nrf2 pathway may be activated in cancers but its pharmacological activators are useful in chemoprevention. äKeap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell meta(epmc).pdf DeepDyve Pubget Overpricing