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10.3390/ijms160921775 http://scihub22266oqcxt.onion/10.3390/ijms160921775 C4613279!4613279 !26370989     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26370989 &cmd=llinks): Failed to open stream: HTTP request failed! 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Tetramethylpyrazine Protects Retinal Capillary Endothelial Cells (TR-iBRB2) against IL-1?-Induced Nitrative/Oxidative Stress |pdf=|usr=}}{{26370989 }} gab.com Text Tetramethylpyrazine Protects Retinal Capillary Endothelial Cells (TR-iBRB2) against IL-1 -Induced Nitrative/Oxidative Stress JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26370989 #FOAvip Blood-retinal barrier (BRB) breakdown is one of the primary causes of diabetic retinopathy (DR). The pro-inflammatory factor interleukin-1? (IL-1?) was reported to be involved in the induction of BRB breakdown during the pathogenesis of DR. In the present study, we investigated the protective effect of tetramethylpyrazine (TMP), a major active component of the traditional herb Ligusticum chuanxiong, on IL-1?-induced cell death of the rat retinal capillary endothelial TR-iBRB2 cells. Our results showed that IL-1?-induced cell dysfunction in TR-iBRB2 cells via inducing nitrative/oxidative stress; however, such effect was attenuated with the pre-treatment of TMP. The cellular protective effect of TMP was likely to be mediated through the inhibition of inducible nitric oxide synthase (iNOS) expression and leukostasis as well as suppression of reactive oxygen species (ROS) generation, mitochondrial dysfunction and MAPKs activation. These findings significantly contribute to a better understanding of the protective effect of TMP in DR and form the basis of the therapeutic development of TMP in treating such disease in the future. Twit Text FOAVip Tetramethylpyrazine Protects Retinal Capillary Endothelial Cells (TR-iBRB2) against IL-1 -Induced Nitrative/Oxidative Stress ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26370989 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26370989 #FOAvip English Wikipedia <ref>{{Cite pmid|26370989 }}</ref> Tetramethylpyrazine Protects Retinal Capillary Endothelial Cells (TR-iBRB2) against IL-1?-Induced Nitrative/Oxidative Stress #MMPMID26370989 Zhu X ; Wang K ; Zhang K ; Tan X ; Wu Z ; Sun S ; Zhou F ; Zhu L Int J Mol Sci 2015[Sep]; 16 (9 ): 21775-90 PMID26370989 show ga Blood-retinal barrier (BRB) breakdown is one of the primary causes of diabetic retinopathy (DR). The pro-inflammatory factor interleukin-1? (IL-1?) was reported to be involved in the induction of BRB breakdown during the pathogenesis of DR. In the present study, we investigated the protective effect of tetramethylpyrazine (TMP), a major active component of the traditional herb Ligusticum chuanxiong, on IL-1?-induced cell death of the rat retinal capillary endothelial TR-iBRB2 cells. Our results showed that IL-1?-induced cell dysfunction in TR-iBRB2 cells via inducing nitrative/oxidative stress; however, such effect was attenuated with the pre-treatment of TMP. The cellular protective effect of TMP was likely to be mediated through the inhibition of inducible nitric oxide synthase (iNOS) expression and leukostasis as well as suppression of reactive oxygen species (ROS) generation, mitochondrial dysfunction and MAPKs activation. These findings significantly contribute to a better understanding of the protective effect of TMP in DR and form the basis of the therapeutic development of TMP in treating such disease in the future. |*Oxidative Stress/drug effects [MESH] |Animals [MESH] |Apoptosis/drug effects [MESH] |Blood-Retinal Barrier/*drug effects/*metabolism [MESH] |Cell Adhesion/drug effects [MESH] |Cell Line [MESH] |Cell Nucleus/metabolism [MESH] |Endothelial Cells/*drug effects/*metabolism [MESH] |Gene Expression Regulation/drug effects [MESH] |Intercellular Adhesion Molecule-1/genetics/metabolism [MESH] |Interleukin-1beta/*metabolism/pharmacology [MESH] |Leukocytes/drug effects/metabolism [MESH] |Mitochondria/drug effects/metabolism [MESH] |Mitogen-Activated Protein Kinases/metabolism [MESH] |NF-kappa B/metabolism [MESH] |Nitrates/*metabolism [MESH] |Nitric Oxide Synthase Type II/genetics/metabolism [MESH] |Phosphorylation [MESH] |Protective Agents/pharmacology [MESH] |Protein Transport/drug effects [MESH] |Pyrazines/*pharmacology [MESH] |Rats [MESH]Tetramethylpyrazine Protects Retinal Capillary Endothelial Cells (TR-i(epmc).pdf DeepDyve Pubget Overpricing