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10.3390/ijms160921277 http://scihub22266oqcxt.onion/10.3390/ijms160921277 C4613252!4613252 !26370962     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26370962 &cmd=llinks): Failed to open stream: HTTP request failed! 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To Extinguish the Fire from Outside the Cell or to Shutdown the Gas Valve Inside? Novel Trends in Anti-Inflammatory Therapies |pdf=|usr=}}{{26370962 }} gab.com Text To Extinguish the Fire from Outside the Cell or to Shutdown the Gas Valve Inside Novel Trends in Anti-Inflammatory Therapies JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26370962 #FOAvip Cytokines are the most important soluble mediators of inflammation. Rare pediatric diseases provided exemplar conditions to study the anti-inflammatory efficacy of new generation therapies (biologics/biopharmaceuticals) selectively targeting single cytokines. Monoclonal antibodies and recombinant proteins have revolutionized anti-inflammatory therapies in the last two decades, allowing the specific targeting of single cytokines. They are very effective in extinguishing inflammation from outside the cell, even with the risk of an excessive and prolonged immunosuppression. Small molecules can enter the cell and shutdown the valve of inflammation by directly targeting signal proteins involved in cytokine release or in response to cytokines. They are orally-administrable drugs whose dosage can be easily adjusted to obtain the desired anti-inflammatory effect. This could make these drugs more suitable for a wide range of diseases as stroke, gout, or neurological impairment, where inflammatory activation plays a pivotal role as trigger. Autoinflammatory diseases, which have previously put anti-cytokine proteins in the limelight, can again provide a valuable model to measure the real potential of small inhibitors as anti-inflammatory agents. Twit Text FOAVip To Extinguish the Fire from Outside the Cell or to Shutdown the Gas Valve Inside Novel Trends in Anti-Inflammatory Therapies ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26370962 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26370962 #FOAvip English Wikipedia <ref>{{Cite pmid|26370962 }}</ref> To Extinguish the Fire from Outside the Cell or to Shutdown the Gas Valve Inside? Novel Trends in Anti-Inflammatory Therapies #MMPMID26370962 Marcuzzi A ; Piscianz E ; Valencic E ; Monasta L ; Vecchi Brumatti L ; Tommasini A Int J Mol Sci 2015[Sep]; 16 (9 ): 21277-93 PMID26370962 show ga Cytokines are the most important soluble mediators of inflammation. Rare pediatric diseases provided exemplar conditions to study the anti-inflammatory efficacy of new generation therapies (biologics/biopharmaceuticals) selectively targeting single cytokines. Monoclonal antibodies and recombinant proteins have revolutionized anti-inflammatory therapies in the last two decades, allowing the specific targeting of single cytokines. They are very effective in extinguishing inflammation from outside the cell, even with the risk of an excessive and prolonged immunosuppression. Small molecules can enter the cell and shutdown the valve of inflammation by directly targeting signal proteins involved in cytokine release or in response to cytokines. They are orally-administrable drugs whose dosage can be easily adjusted to obtain the desired anti-inflammatory effect. This could make these drugs more suitable for a wide range of diseases as stroke, gout, or neurological impairment, where inflammatory activation plays a pivotal role as trigger. Autoinflammatory diseases, which have previously put anti-cytokine proteins in the limelight, can again provide a valuable model to measure the real potential of small inhibitors as anti-inflammatory agents. |Animals [MESH] |Anti-Inflammatory Agents/pharmacology/*therapeutic use [MESH] |Biological Products/pharmacology/therapeutic use [MESH] |Cryopyrin-Associated Periodic Syndromes/diagnosis/drug therapy/etiology/metabolism [MESH] |Humans [MESH] |Inflammation/diagnosis/drug therapy/*etiology/*metabolism [MESH]To Extinguish the Fire from Outside the Cell or to Shutdown the Gas Va(epmc).pdf DeepDyve Pubget Overpricing