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10.3390/ijms160920417 http://scihub22266oqcxt.onion/10.3390/ijms160920417 C4613211!4613211 !26343645     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26343645 &cmd=llinks): Failed to open stream: HTTP request failed! 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Photodynamic and Antibiotic Therapy in Combination to Fight Biofilms and Resistant Surface Bacterial Infections |pdf=|usr=}}{{26343645 }} gab.com Text Photodynamic and Antibiotic Therapy in Combination to Fight Biofilms and Resistant Surface Bacterial Infections JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26343645 #FOAvip Although photodynamic therapy (PDT), a therapeutic approach that involves a photosensitizer, light and O?, has been principally considered for the treatment of specific types of cancers, other applications exist, including the treatment of infections. Unfortunately, PDT does not always guarantee full success since it exerts lethal effects only in cells that have taken up a sufficient amount of photosensitizer and have been exposed to adequate light doses, conditions that are not always achieved. Based on our previous experience on the combination PDT/chemotherapy, we have explored the possibility of fighting bacteria that commonly crowd infected surfaces by combining PDT with an antibiotic, which normally does not harm the strain at low concentrations. To this purpose, we employed 5-aminolevulinic acid (5-ALA), a pro-drug that, once absorbed by proliferating bacteria, is converted into the natural photosensitizer Protoporphyrin IX (PpIX), followed by Gentamicin. Photoactivation generates reactive oxygen species (ROS) which damage or kill the cell, while Gentamicin, even at low doses, ends the work. Our experiments, in combination, have been highly successful against biofilms produced by several Gram positive bacteria (i.e., Staphylococcus aureus, Staphylococcus epidermidis, etc.). This original approach points to potentially new and wide applications in the therapy of infections of superficial wounds and sores. Twit Text FOAVip Photodynamic and Antibiotic Therapy in Combination to Fight Biofilms and Resistant Surface Bacterial Infections ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26343645 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26343645 #FOAvip English Wikipedia <ref>{{Cite pmid|26343645 }}</ref> Photodynamic and Antibiotic Therapy in Combination to Fight Biofilms and Resistant Surface Bacterial Infections #MMPMID26343645 Barra F ; Roscetto E ; Soriano AA ; Vollaro A ; Postiglione I ; Pierantoni GM ; Palumbo G ; Catania MR Int J Mol Sci 2015[Aug]; 16 (9 ): 20417-30 PMID26343645 show ga Although photodynamic therapy (PDT), a therapeutic approach that involves a photosensitizer, light and O?, has been principally considered for the treatment of specific types of cancers, other applications exist, including the treatment of infections. Unfortunately, PDT does not always guarantee full success since it exerts lethal effects only in cells that have taken up a sufficient amount of photosensitizer and have been exposed to adequate light doses, conditions that are not always achieved. Based on our previous experience on the combination PDT/chemotherapy, we have explored the possibility of fighting bacteria that commonly crowd infected surfaces by combining PDT with an antibiotic, which normally does not harm the strain at low concentrations. To this purpose, we employed 5-aminolevulinic acid (5-ALA), a pro-drug that, once absorbed by proliferating bacteria, is converted into the natural photosensitizer Protoporphyrin IX (PpIX), followed by Gentamicin. Photoactivation generates reactive oxygen species (ROS) which damage or kill the cell, while Gentamicin, even at low doses, ends the work. Our experiments, in combination, have been highly successful against biofilms produced by several Gram positive bacteria (i.e., Staphylococcus aureus, Staphylococcus epidermidis, etc.). This original approach points to potentially new and wide applications in the therapy of infections of superficial wounds and sores. |*Drug Resistance, Bacterial [MESH] |*Light [MESH] |*Photochemotherapy [MESH] |Anti-Bacterial Agents/*pharmacology [MESH] |Bacteria/*drug effects [MESH] |Biofilms/*drug effects [MESH] |Gentamicins/pharmacology [MESH] |Microbial Sensitivity Tests [MESH] |Microscopy, Confocal [MESH]Photodynamic and Antibiotic Therapy in Combination to Fight Biofilms a(epmc).pdf DeepDyve Pubget Overpricing