Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26550172
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Int+J+Clin+Exp+Med
2015 ; 8
(8
): 12609-16
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Long non-coding RNA UCA1 contributes to the progression of prostate cancer and
regulates proliferation through KLF4-KRT6/13 signaling pathway
#MMPMID26550172
Na XY
; Liu ZY
; Ren PP
; Yu R
; Shang XS
Int J Clin Exp Med
2015[]; 8
(8
): 12609-16
PMID26550172
show ga
Long non-coding RNAs (lncRNAs) UCA1 have been shown to paly an important
regulatory roles in cancer biology, and UCA1 dysfunction is related to TNM stage,
metastasis and postoperative survival in several cancers. However, the biological
role and clinical significance of UCA1 in the carcinogenesis of prostate cancer
(PC) remain largely unclear. Herein, we found that UCA1 was abnormally
upregulated in tumor tissues from PC patients, and patients with high UCA1 levels
had a significantly poorer prognosis. Intriguingly, the mRNA and protein levels
of KLF4 were significantly increased in tumor tissues, which was highly
correlated to UCA1 levels. Moreover, UCA1 depletion inhibited the growth and
induced apoptosis in PC3 and LNCaP cell lines. In addition, UCA1 loss-of-function
could decrease KLF4 expression, subsequently, the downregulation of KRT6 and
KRT13. Taken together, our study indicated that UCA1 had a crucial role in the
tumorigenesis of PC. Moreover, UCA1 loss-of-function inhibited cell proliferation
and induced cell apoptosis, at least partially, through inactivation KLF4-KRT6/13
cascade.