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2015 ; 38
(3
): 308-15
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Occupational exposure of workers to pesticides: Toxicogenetics and susceptibility
gene polymorphisms
#MMPMID26500434
Adad LM
; de Andrade HH
; Kvitko K
; Lehmann M
; Cavalcante AA
; Dihl RR
Genet Mol Biol
2015[Jul]; 38
(3
): 308-15
PMID26500434
show ga
Farm workers are often exposed to pesticides, which are products belonging to a
specific chemical group that affects the health of agricultural workers and is
mostly recognized as genotoxic and carcinogenic. The exposure of workers from
Piauí, Brazil, to these hazardous chemicals was assessed and cytogenetic
alterations were evaluated using the buccal micronucleus assay, hematological and
lipid parameters, butyrylcholinesterase (BChE) activity and genetic polymorphisms
of enzymes involved in the metabolism of pesticides, such as PON1, as well as of
the DNA repair system (OGG1, XRCC1 and XRCC4). Two groups of farm workers exposed
to different types of pesticides were evaluated and compared to matched
non-exposed control groups. A significant increase was observed in the
frequencies of micronuclei, kariorrhexis, karyolysis and binucleated cells in the
exposed groups (n = 100) compared to controls (n = 100). No differences were
detected regarding the hematological parameters, lipid profile and BChE activity.
No significant difference was observed either regarding DNA damage or nuclear
fragmentation when specific metabolizing and DNA repair genotypes were
investigated in the exposed groups.