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10.1080/15384101.2015.1022698 http://scihub22266oqcxt.onion/10.1080/15384101.2015.1022698 C4612563!4612563!25789413     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Cycle 2015 ; 14 (9): 1365-9 Nephropedia Template TP {{tp|p=25789413|t=2015. Mitochondrial fragmentation in excitotoxicity requires ROCK activation |pdf=|usr=}}{{25789413}} gab.com Text Mitochondrial fragmentation in excitotoxicity requires ROCK activation JO: Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=25789413 #FOAvip Mitochondria morphology constantly changes through fission and fusion processes that regulate mitochondrial function, and it therefore plays a prominent role in cellular homeostasis. Cell death progression is associated with mitochondrial fission. Fission is mediated by the mainly cytoplasmic Drp1, which is activated by different post-translational modifications and recruited to mitochondria to perform its function. Our research and other studies have shown that in the early moments of excitotoxic insult Drp1 must be nitrosylated to mediate mitochondrial fragmentation in neurons. Nonetheless, mitochondrial fission is a multistep process in which filamentous actin assembly/disassembly and myosin-mediated mitochondrial constriction play prominent roles. Here we establish that in addition to nitric oxide production, excitotoxicity-induced mitochondrial fragmentation also requires activation of the actomyosin regulator ROCK. Although ROCK1 has been shown to phosphorylate and activate Drp1, experiments using phosphor-mutant forms of Drp1 in primary cortical neurons indicate that in excitotoxic conditions, ROCK does not act directly on Drp1 to mediate fission, but may act on the actomyosin complex. Thus, these data indicate that a wider range of signaling pathways than those that target Drp1 are amenable to be inhibited to prevent mitochondrial fragmentation as therapeutic option. Twit Text FOAVip Mitochondrial fragmentation in excitotoxicity requires ROCK activation ????Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=25789413 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25789413 #FOAvip English Wikipedia <ref>{{Cite pmid|25789413}}</ref> Mitochondrial fragmentation in excitotoxicity requires ROCK activation #MMPMID25789413 Martorell-Riera A; Segarra-Mondejar M; Reina M; Martínez-Estrada OM; Soriano FX Cell Cycle 2015[May]; 14 (9): 1365-9 PMID25789413show ga Mitochondria morphology constantly changes through fission and fusion processes that regulate mitochondrial function, and it therefore plays a prominent role in cellular homeostasis. Cell death progression is associated with mitochondrial fission. Fission is mediated by the mainly cytoplasmic Drp1, which is activated by different post-translational modifications and recruited to mitochondria to perform its function. Our research and other studies have shown that in the early moments of excitotoxic insult Drp1 must be nitrosylated to mediate mitochondrial fragmentation in neurons. Nonetheless, mitochondrial fission is a multistep process in which filamentous actin assembly/disassembly and myosin-mediated mitochondrial constriction play prominent roles. Here we establish that in addition to nitric oxide production, excitotoxicity-induced mitochondrial fragmentation also requires activation of the actomyosin regulator ROCK. Although ROCK1 has been shown to phosphorylate and activate Drp1, experiments using phosphor-mutant forms of Drp1 in primary cortical neurons indicate that in excitotoxic conditions, ROCK does not act directly on Drp1 to mediate fission, but may act on the actomyosin complex. Thus, these data indicate that a wider range of signaling pathways than those that target Drp1 are amenable to be inhibited to prevent mitochondrial fragmentation as therapeutic option. äMitochondrial fragmentation in excitotoxicity requires ROCK activation(epmc).pdf DeepDyve Pubget Overpricing