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10.1084/jem.20150632

http://scihub22266oqcxt.onion/10.1084/jem.20150632
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C4612096!4612096!26392224
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suck abstract from ncbi


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pmid26392224      J+Exp+Med 2015 ; 212 (11): 1851-68
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  • Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome?CoV infection #MMPMID26392224
  • Vijay R; Hua X; Meyerholz DK; Miki Y; Yamamoto K; Gelb M; Murakami M; Perlman S
  • J Exp Med 2015[Oct]; 212 (11): 1851-68 PMID26392224show ga
  • Vijay et al. show that an age-dependent increase of phospholipase A2 group IID (PLA2G2D) in the lung contributes to worse outcomes in mice infected with SARS-CoV. Mice lacking (PLA2G2D) had increased survival to lethal infection with enhanced DC migration to the dLN and augmented T cell responses. The results suggest that targeting (PLA2G2D) in elderly patients with respiratory infections could represent an attractive therapeutic strategy.
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