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10.1038/cddis.2014.250 http://scihub22266oqcxt.onion/10.1038/cddis.2014.250 C4611723!4611723 !24922077     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24922077 &cmd=llinks): Failed to open stream: HTTP request failed! 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Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening |pdf=|usr=}}{{24922077 }} gab.com Text Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=24922077 #FOAvip STAT3 regulates a variety of genes involved with cell proliferation, differentiation, apoptosis, angiogenesis, metastasis, inflammation, and immunity. The purpose of this study was to apply molecular docking techniques to identify STAT3 inhibitors from a database of over 90000 natural product and natural product-like compounds. The virtual screening campaign furnished 14 hit compounds, from which compound 1 emerged as a top candidate. Compound 1 inhibited STAT3 DNA-binding activity in vitro and attenuated STAT3-directed transcription in cellulo with selectivity over STAT1 and with comparable potency to the well-known STAT3 inhibitor S3I-201. Furthermore, compound 1 inhibited STAT3 dimerization and decreased STAT3 phosphorylation in cells without affecting STAT1 dimerization and phosphorylation. Compound 1 also exhibited selective anti-proliferative activity against cancer cells over normal cells in vitro. Molecular docking analysis suggested that compound 1 might putatively function as an inhibitor of STAT3 dimerization by binding to the SH2 domain. This study also validates the use of in silico techniques to identify inhibitors of protein-protein interactions, which are typically considered difficult to target with small molecules. Twit Text FOAVip Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=24922077 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24922077 #FOAvip English Wikipedia <ref>{{Cite pmid|24922077 }}</ref> Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening #MMPMID24922077 Liu LJ ; Leung KH ; Chan DS ; Wang YT ; Ma DL ; Leung CH Cell Death Dis 2014[Jun]; 5 (6 ): e1293 PMID24922077 show ga STAT3 regulates a variety of genes involved with cell proliferation, differentiation, apoptosis, angiogenesis, metastasis, inflammation, and immunity. The purpose of this study was to apply molecular docking techniques to identify STAT3 inhibitors from a database of over 90000 natural product and natural product-like compounds. The virtual screening campaign furnished 14 hit compounds, from which compound 1 emerged as a top candidate. Compound 1 inhibited STAT3 DNA-binding activity in vitro and attenuated STAT3-directed transcription in cellulo with selectivity over STAT1 and with comparable potency to the well-known STAT3 inhibitor S3I-201. Furthermore, compound 1 inhibited STAT3 dimerization and decreased STAT3 phosphorylation in cells without affecting STAT1 dimerization and phosphorylation. Compound 1 also exhibited selective anti-proliferative activity against cancer cells over normal cells in vitro. Molecular docking analysis suggested that compound 1 might putatively function as an inhibitor of STAT3 dimerization by binding to the SH2 domain. This study also validates the use of in silico techniques to identify inhibitors of protein-protein interactions, which are typically considered difficult to target with small molecules. |*Protein Multimerization [MESH] |Antineoplastic Agents/*chemistry [MESH] |Drug Screening Assays, Antitumor/methods [MESH] |HeLa Cells [MESH] |Hep G2 Cells [MESH] |Humans [MESH] |Molecular Docking Simulation/*methods [MESH] |STAT1 Transcription Factor [MESH] |STAT3 Transcription Factor/*antagonists & inhibitors/genetics/metabolism [MESH]Identification of a natural product-like STAT3 dimerization inhibitor (epmc).pdf DeepDyve Pubget Overpricing