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10.4049/jimmunol.1500945 http://scihub22266oqcxt.onion/10.4049/jimmunol.1500945 C4610862!4610862!26408668     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2015 ; 195 (9): 4154-61 Nephropedia Template TP {{tp|p=26408668|t=2015. Requirement for CD28 in Effector Treg Differentiation, CCR6 induction, and Skin Homing |pdf=|usr=}}{{26408668}} gab.com Text Requirement for CD28 in Effector Treg Differentiation, CCR6 induction, and Skin Homing JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26408668 #FOAvip The skin, like most non-lymphoid tissues, contains substantial numbers of T cells. Among these, memory T cells serve a sentinel role to protect against pathogens, and regulatory T cells terminate immune responses as a check against unrestrained inflammation. Previously, we created conditional knockout mice with Treg-specific deletion of CD28. Although these mice have normal numbers of Tregs, these cells have lower levels of CTLA-4, PD-1 and CCR6, and the animals develop systemic autoimmunity characterized by prominent skin inflammation. Here, we have performed a detailed analysis of the skin disease in these mice. Our data show that Treg-expressed CD28 is required for optimal maturation of CD44loCD62Lhi central Tregs (cTreg) into CD44hiCD62Llo effector Tregs (eTregs), and induction of CCR6 among the cells that do become eTregs. While CD28-deficient Tregs are able to regulate inflammation normally when injected directly into the skin, they fail to home properly to inflamed skin. Collectively, these results suggest a key role for CD28 costimulation in promoting a cTreg to eTreg transition with appropriate upregulation of appropriate chemokine receptors such as CCR6 that are required for tissue homing. Twit Text FOAVip Requirement for CD28 in Effector Treg Differentiation, CCR6 induction, and Skin Homing ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26408668 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26408668 #FOAvip English Wikipedia <ref>{{Cite pmid|26408668}}</ref> Requirement for CD28 in Effector Treg Differentiation, CCR6 induction, and Skin Homing #MMPMID26408668 Zhang R; Borges CM; Fan MY; Harris JE; Turka LA J Immunol 2015[Nov]; 195 (9): 4154-61 PMID26408668show ga The skin, like most non-lymphoid tissues, contains substantial numbers of T cells. Among these, memory T cells serve a sentinel role to protect against pathogens, and regulatory T cells terminate immune responses as a check against unrestrained inflammation. Previously, we created conditional knockout mice with Treg-specific deletion of CD28. Although these mice have normal numbers of Tregs, these cells have lower levels of CTLA-4, PD-1 and CCR6, and the animals develop systemic autoimmunity characterized by prominent skin inflammation. Here, we have performed a detailed analysis of the skin disease in these mice. Our data show that Treg-expressed CD28 is required for optimal maturation of CD44loCD62Lhi central Tregs (cTreg) into CD44hiCD62Llo effector Tregs (eTregs), and induction of CCR6 among the cells that do become eTregs. While CD28-deficient Tregs are able to regulate inflammation normally when injected directly into the skin, they fail to home properly to inflamed skin. Collectively, these results suggest a key role for CD28 costimulation in promoting a cTreg to eTreg transition with appropriate upregulation of appropriate chemokine receptors such as CCR6 that are required for tissue homing. äRequirement for CD28 in Effector Treg Differentiation, CCR6 induction,(epmc).pdf DeepDyve Pubget Overpricing