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2015 ; 62
(2
): 319-28
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Real-time integrated photoacoustic and ultrasound (PAUS) imaging system to guide
interventional procedures: ex vivo study
#MMPMID25643081
Wei CW
; Nguyen TM
; Xia J
; Arnal B
; Wong EY
; Pelivanov IM
; O'Donnell M
IEEE Trans Ultrason Ferroelectr Freq Control
2015[Feb]; 62
(2
): 319-28
PMID25643081
show ga
Because of depth-dependent light attenuation, bulky, low-repetition-rate lasers
are usually used in most photoacoustic (PA) systems to provide sufficient pulse
energies to image at depth within the body. However, integrating these lasers
with real-time clinical ultrasound (US) scanners has been problematic because of
their size and cost. In this paper, an integrated PA/US (PAUS) imaging system is
presented operating at frame rates >30 Hz. By employing a portable, low-cost,
low-pulse-energy (~2 mJ/pulse), high-repetition-rate (~1 kHz), 1053-nm laser, and
a rotating galvo-mirror system enabling rapid laser beam scanning over the
imaging area, the approach is demonstrated for potential applications requiring a
few centimeters of penetration. In particular, we demonstrate here real-time (30
Hz frame rate) imaging (by combining multiple single-shot sub-images covering the
scan region) of an 18-gauge needle inserted into a piece of chicken breast with
subsequent delivery of an absorptive agent at more than 1-cm depth to mimic PAUS
guidance of an interventional procedure. A signal-to-noise ratio of more than 35
dB is obtained for the needle in an imaging area 2.8 × 2.8 cm (depth × lateral).
Higher frame rate operation is envisioned with an optimized scanning scheme.