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10.1097/MCO.0000000000000219 http://scihub22266oqcxt.onion/10.1097/MCO.0000000000000219 C4610809!4610809!26335311     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Clin+Nutr+Metab+Care 2015 ; 18 (6): 521-7 Nephropedia Template TP {{tp|p=26335311|t=2015. Sirtuin-Dependent Clock Control: New Advances in Metabolism, Aging and Cancer |pdf=|usr=}}{{26335311}} gab.com Text Sirtuin-Dependent Clock Control: New Advances in Metabolism, Aging and Cancer JO: Curr Opin Clin Nutr Metab Care http://www.kidney.de/pget.php?&tw=1&pmid=26335311 #FOAvip Purpose of review: The circadian clock is an intricate biological timekeeper that is subject to fine-tuning mechanisms in order to maintain synchrony with the surrounding environment. One such mechanism is performed by the mammalian sirtuins that provide plasticity to the circadian clock by sensing cellular metabolic state. The sirtuins modulate the circadian epigenome and subsequent transcriptional control, and alterations to this organized system manifest in metabolic consequences, aging phenotypes and possibly cancer. Recent findings: New information regarding sirtuin-dependent control of the circadian clock has emerged. In addition to SIRT1 and SIRT3, SIRT6 has been demonstrated as a critical regulator of circadian transcription that also serves as an interface with metabolic homeostasis. Also, new metabolic functions of SIRT1 have been described in the brain, which are critical to relay nutritional inputs to the central clock. Summary: This review focuses on the link between the circadian clock and the sirtuins, with an emphasis on new findings. In addition, speculation on the possible connections at the physiological level will be made that could further link the clock to aging and cancer. Twit Text FOAVip Sirtuin-Dependent Clock Control: New Advances in Metabolism, Aging and Cancer ????Curr Opin Clin Nutr Metab Care http://www.kidney.de/pget.php?&tw=1&pmid=26335311 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26335311 #FOAvip English Wikipedia <ref>{{Cite pmid|26335311}}</ref> Sirtuin-Dependent Clock Control: New Advances in Metabolism, Aging and Cancer #MMPMID26335311 Masri S Curr Opin Clin Nutr Metab Care 2015[Nov]; 18 (6): 521-7 PMID26335311show ga Purpose of review: The circadian clock is an intricate biological timekeeper that is subject to fine-tuning mechanisms in order to maintain synchrony with the surrounding environment. One such mechanism is performed by the mammalian sirtuins that provide plasticity to the circadian clock by sensing cellular metabolic state. The sirtuins modulate the circadian epigenome and subsequent transcriptional control, and alterations to this organized system manifest in metabolic consequences, aging phenotypes and possibly cancer. Recent findings: New information regarding sirtuin-dependent control of the circadian clock has emerged. In addition to SIRT1 and SIRT3, SIRT6 has been demonstrated as a critical regulator of circadian transcription that also serves as an interface with metabolic homeostasis. Also, new metabolic functions of SIRT1 have been described in the brain, which are critical to relay nutritional inputs to the central clock. Summary: This review focuses on the link between the circadian clock and the sirtuins, with an emphasis on new findings. In addition, speculation on the possible connections at the physiological level will be made that could further link the clock to aging and cancer. äSirtuin-Dependent Clock Control: New Advances in Metabolism, Aging and(epmc).pdf DeepDyve Pubget Overpricing