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The Antioxidative Effect of Chamomile, Anthocyanoside and their Combination on
Bleomycin-induced Pulmonary Fibrosis in Rat
#MMPMID26543307
Javadi I
; Emami S
Med Arch
2015[Aug]; 69
(4
): 229-31
PMID26543307
show ga
INTRODUCTION: Bleomycin is a small peptide with 1500Daltun of molecular weight
which has two junction areas in two molecule's opposite sides, one of them to
relate to the DNA and the other to relate to the iron. Iron is a crucially
important factor in free radical production and cytotoxic activity of bleomycin.
MATERIAL AND METHODS: The study attempts to study, and compare, the effect of
using Chamomile, Anthocyanoside and their combination, as anti-inflammatory agent
to ameliorates, to prevent or control the development of fibrosis due to
Bleomycin (BLM). to prepare pulmonary fibrosis model, male Wistar rats weighting
180-220g were assigned to specific groups Rats of each group received
intratracheally 1U/100 g of BLM. 20 rats were divided to five comparable groups,
as(1) BLM group, (2) saline group, (3) Chamomile group, (4) Anthocyanoside group,
(5) combination of Anthocyanoside and Chamomile group. Antioxidative combinations
were given as pretreatment and treatment after the rats received Bleomycine.
RESULTS: After 3 week, Malondialdehyde (MDA)was measured for each rat's lung.
After three weeks, MDA was reduced, compared to BLM group, to 44.27%, 37.80% and
46.07% in Anthocyanoside, Chamomiland combination group, respectively. It was
concluded from the present study that administration of combination of Chamomile
and Anthocyanoside lead to a significant reduction in Bleomycin-induced MDA.
CONCLUSION: The mechanism of the effect of these combinations is possibly the
result of phenolic combinations as antioxidant and oxy free radical scavenger and
inhibitor of lipid peroxidation.
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