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10.1111/imm.12522 http://scihub22266oqcxt.onion/10.1111/imm.12522 C4610634!4610634!26271466     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunology 2015 ; 146 (3): 456-69 Nephropedia Template TP {{tp|p=26271466|t=2015. Thymic emigration patterns in patients with type 2 diabetes treated with metformin |pdf=|usr=}}{{26271466}} gab.com Text Thymic emigration patterns in patients with type 2 diabetes treated with metformin JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=26271466 #FOAvip Recent data suggest that thymic output, which provides the naive T cells necessary for the normal functioning of T-cell-dependent immunosurveillance cellular immunity including anti-cancer protection, can be disturbed in the course of type 2 diabetes. Metformin, an anti-diabetic drug commonly confirmed as an agent with many potential anti-cancer activities, might be helpful in this immune correction. The profile of thymic output was evaluated in the current study on the basis of the signal-joint T-cell receptor excision circle (sjTREC) concentration in peripheral blood polymorphonuclear cells and thymic emigrant content in peripheral blood evaluated from CD127 and/or CD132 antigen expression. It was revealed that recent thymic emigrants and more differentiated CD127+ CD132+ cell populations were decreased among naive T cells and CD8+ T cells, whereas RTE count was increased in CD4+ T cells, and the CD127+ CD132+ cell population was less numerous than in non-diabetic participants. Terminally differentiated thymic emigrants, i.e. CD127? CD132+ cells, were increased in naive T cells and in CD8+ T cells. Metformin affects mainly the early phases of thymic export, increasing CD127+ CD132? and CD127+ CD132+ cell populations in naive T cells and the CD127+ CD132? population in CD4+ T lymphocytes. It could be concluded that type 2 diabetes deteriorates thymic immunostasis. The decreased thymic output could be compensated by metformin, especially with regard to CD4+ naive T cells. It is the first time that therapy with metformin has been documented by us as particularly useful in the control and normalization of thymus function, regarding correction of early populations of thymic emigrants. Twit Text FOAVip Thymic emigration patterns in patients with type 2 diabetes treated with metformin ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=26271466 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26271466 #FOAvip English Wikipedia <ref>{{Cite pmid|26271466}}</ref> Thymic emigration patterns in patients with type 2 diabetes treated with metformin #MMPMID26271466 Dworacki G; Urazayev O; Bekmukhambetov Y; Iskakova S; Frycz BA; Jagodzi?ski PP; Dworacka M Immunology 2015[Nov]; 146 (3): 456-69 PMID26271466show ga Recent data suggest that thymic output, which provides the naive T cells necessary for the normal functioning of T-cell-dependent immunosurveillance cellular immunity including anti-cancer protection, can be disturbed in the course of type 2 diabetes. Metformin, an anti-diabetic drug commonly confirmed as an agent with many potential anti-cancer activities, might be helpful in this immune correction. The profile of thymic output was evaluated in the current study on the basis of the signal-joint T-cell receptor excision circle (sjTREC) concentration in peripheral blood polymorphonuclear cells and thymic emigrant content in peripheral blood evaluated from CD127 and/or CD132 antigen expression. It was revealed that recent thymic emigrants and more differentiated CD127+ CD132+ cell populations were decreased among naive T cells and CD8+ T cells, whereas RTE count was increased in CD4+ T cells, and the CD127+ CD132+ cell population was less numerous than in non-diabetic participants. Terminally differentiated thymic emigrants, i.e. CD127? CD132+ cells, were increased in naive T cells and in CD8+ T cells. Metformin affects mainly the early phases of thymic export, increasing CD127+ CD132? and CD127+ CD132+ cell populations in naive T cells and the CD127+ CD132? population in CD4+ T lymphocytes. It could be concluded that type 2 diabetes deteriorates thymic immunostasis. The decreased thymic output could be compensated by metformin, especially with regard to CD4+ naive T cells. It is the first time that therapy with metformin has been documented by us as particularly useful in the control and normalization of thymus function, regarding correction of early populations of thymic emigrants. äThymic emigration patterns in patients with type 2 diabetes treated wi(epmc).pdf DeepDyve Pubget Overpricing