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10.1111/imm.12519 http://scihub22266oqcxt.onion/10.1111/imm.12519 C4610631!4610631!26251265     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunology 2015 ; 146 (3): 423-31 Nephropedia Template TP {{tp|p=26251265|t=2015. 1?,25-dihydroxyvitamin D3 acts via transforming growth factor-? to up-regulate expression of immunosuppressive CD73 on human CD4+ Foxp3? T cells |pdf=|usr=}}{{26251265}} gab.com Text 1 ,25-dihydroxyvitamin D3 acts via transforming growth factor- to up-regulate expression of immunosuppressive CD73 on human CD4+ Foxp3 T cells JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=26251265 #FOAvip Vitamin D deficiency is associated with increased incidence and severity of various immune-mediated diseases. Active vitamin D (1?,25-dihydroxyvitamin D3; 1,25(OH)2D3) up-regulates CD4+ T-cell expression of the purine ectonucleotidase CD39, a molecule that is associated with the generation of anti-inflammatory adenosine. Here we aimed to investigate the direct impact of 1,25(OH)2D3 on expression of the downstream ecto-5?-nucleotidase CD73 by human CD4 T cells, and components of the transforming growth factor-? (TGF-?) pathway, which have been implicated in the modulation of CD73 by murine T cells. At 10?8 to 10?7m, 1,25(OH)2D3 significantly increased expression of CD73 on peripheral human CD4+ T cells. Although 1,25(OH)2D3 did not affect the mRNA expression of latent TGF-?1, 1,25(OH)2D3 did up-regulate expression of TGF-?-associated molecules [latency-associated peptide (LAP), glycophorin A repetitions predominant (GARP), GP96, neuropilin-1, thrombospondin-1 and ?v integrin] which is likely to have contributed to the observed enhancement in TGF-? bioactivity. CD73 was highly co-expressed with LAP and GARP following 1,25(OH)2D3 treatment, but unexpectedly, each of these cell surface molecules was expressed primarily on CD4+ Foxp3? T cells, rather than CD4+ Foxp3+ T cells. Notably, neutralization of TGF-? significantly impaired 1,25(OH)2D3-mediated induction of CD73. Collectively, we show that 1,25(OH)2D3 enhances expression of CD73 on CD4+ Foxp3? T cells in a process that is at least partially TGF-?-dependent. These data reveal an additional contributing mechanism by which vitamin D may be protective in immune-mediated disease. Twit Text FOAVip 1 ,25-dihydroxyvitamin D3 acts via transforming growth factor- to up-regulate expression of immunosuppressive CD73 on human CD4+ Foxp3 T cells ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=26251265 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26251265 #FOAvip English Wikipedia <ref>{{Cite pmid|26251265}}</ref> 1?,25-dihydroxyvitamin D3 acts via transforming growth factor-? to up-regulate expression of immunosuppressive CD73 on human CD4+ Foxp3? T cells #MMPMID26251265 Mann EH; Chambers ES; Chen YH; Richards DF; Hawrylowicz CM Immunology 2015[Nov]; 146 (3): 423-31 PMID26251265show ga Vitamin D deficiency is associated with increased incidence and severity of various immune-mediated diseases. Active vitamin D (1?,25-dihydroxyvitamin D3; 1,25(OH)2D3) up-regulates CD4+ T-cell expression of the purine ectonucleotidase CD39, a molecule that is associated with the generation of anti-inflammatory adenosine. Here we aimed to investigate the direct impact of 1,25(OH)2D3 on expression of the downstream ecto-5?-nucleotidase CD73 by human CD4 T cells, and components of the transforming growth factor-? (TGF-?) pathway, which have been implicated in the modulation of CD73 by murine T cells. At 10?8 to 10?7m, 1,25(OH)2D3 significantly increased expression of CD73 on peripheral human CD4+ T cells. Although 1,25(OH)2D3 did not affect the mRNA expression of latent TGF-?1, 1,25(OH)2D3 did up-regulate expression of TGF-?-associated molecules [latency-associated peptide (LAP), glycophorin A repetitions predominant (GARP), GP96, neuropilin-1, thrombospondin-1 and ?v integrin] which is likely to have contributed to the observed enhancement in TGF-? bioactivity. CD73 was highly co-expressed with LAP and GARP following 1,25(OH)2D3 treatment, but unexpectedly, each of these cell surface molecules was expressed primarily on CD4+ Foxp3? T cells, rather than CD4+ Foxp3+ T cells. Notably, neutralization of TGF-? significantly impaired 1,25(OH)2D3-mediated induction of CD73. Collectively, we show that 1,25(OH)2D3 enhances expression of CD73 on CD4+ Foxp3? T cells in a process that is at least partially TGF-?-dependent. These data reveal an additional contributing mechanism by which vitamin D may be protective in immune-mediated disease. ä1?,25-dihydroxyvitamin D3 acts via transforming growth factor-? to up-(epmc).pdf DeepDyve Pubget Overpricing