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10.1007/s11515-015-1359-x http://scihub22266oqcxt.onion/10.1007/s11515-015-1359-x C4610405!4610405!26494984     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Biol+(Beijing) 2015 ; 10 (3): 221-9 Nephropedia Template TP {{tp|p=26494984|t=2015. Role of upstream stimulatory factor 2 in diabetic nephropathy |pdf=|usr=}}{{26494984}} gab.com Text Role of upstream stimulatory factor 2 in diabetic nephropathy JO: Front Biol (Beijing) http://www.kidney.de/pget.php?&tw=1&pmid=26494984 #FOAvip Diabetic nephropathy (DN) is the most common cause of end-stage renal disease (ESRD). About 20%?30% of people with type 1 and type 2 diabetes develop DN. DN is characterized by both glomerulosclerosis with thickening of the glomerular basement membrane and mesangial matrix expansion, and tubulointerstitial fibrosis. Hyperglycemia and the activation of the intra-renal renin-angiotensin system (RAS) in diabetes have been suggested to play a critical role in the pathogenesis of DN. However, the mechanisms are not well known.Studies from our laboratory demonstrated that the transcription factor?upstream stimulatory factor 2 (USF2) is an important regulator of DN. Moreover, the renin gene is a downstream target of USF2. Importantly, USF2 transgenic (Tg) mice demonstrate a specific increase in renal renin expression and angiotensin II (AngII) levels in kidney and exhibit increased urinary albumin excretion and extracellular matrix deposition in glomeruli, supporting a role for USF2 in the development of diabetic nephropathy. In this review, we summarize our findings of the mechanisms by which diabetes regulates USF2 in kidney cells and its role in regulation of renal renin-angiotensin system and the development of diabetic nephropathy. Twit Text FOAVip Role of upstream stimulatory factor 2 in diabetic nephropathy ????Front Biol (Beijing) http://www.kidney.de/pget.php?&tw=1&pmid=26494984 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26494984 #FOAvip English Wikipedia <ref>{{Cite pmid|26494984}}</ref> Role of upstream stimulatory factor 2 in diabetic nephropathy #MMPMID26494984 Wang S Front Biol (Beijing) 2015[Jun]; 10 (3): 221-9 PMID26494984show ga Diabetic nephropathy (DN) is the most common cause of end-stage renal disease (ESRD). About 20%?30% of people with type 1 and type 2 diabetes develop DN. DN is characterized by both glomerulosclerosis with thickening of the glomerular basement membrane and mesangial matrix expansion, and tubulointerstitial fibrosis. Hyperglycemia and the activation of the intra-renal renin-angiotensin system (RAS) in diabetes have been suggested to play a critical role in the pathogenesis of DN. However, the mechanisms are not well known.Studies from our laboratory demonstrated that the transcription factor?upstream stimulatory factor 2 (USF2) is an important regulator of DN. Moreover, the renin gene is a downstream target of USF2. Importantly, USF2 transgenic (Tg) mice demonstrate a specific increase in renal renin expression and angiotensin II (AngII) levels in kidney and exhibit increased urinary albumin excretion and extracellular matrix deposition in glomeruli, supporting a role for USF2 in the development of diabetic nephropathy. In this review, we summarize our findings of the mechanisms by which diabetes regulates USF2 in kidney cells and its role in regulation of renal renin-angiotensin system and the development of diabetic nephropathy. äRole of upstream stimulatory factor 2 in diabetic nephropathy (epmc).pdf DeepDyve Pubget Overpricing