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Extracellular Nucleic Acids in Urine: Sources, Structure, Diagnostic Potential #MMPMID26483959
Bryzgunova OE; Laktionov PP
Acta Naturae 2015[Jul]; 7 (3): 48-54 PMID26483959show ga
Cell-free nucleic acids (cfNA) may reach the urine through cell necrosis or apoptosis, active secretion of nucleic acids by healthy and tumor cells of the urinary tract, and transport of circulating nucleic acids (cir- NA) from the blood into primary urine. Even though urinary DNA and RNA are fragmented, they can be used to detect marker sequences. MicroRNAs are also of interest as diagnostic probes. The stability of cfNA in the urine is determined by their structure and packaging into supramolecular complexes and by nuclease activity in the urine. This review summarizes current data on the sources of urinary cfNA, their structural features, diagnostic potential and factors affecting their stability.