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10.1097/QAI.0000000000000741

http://scihub22266oqcxt.onion/10.1097/QAI.0000000000000741
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C4610144!4610144!26473639
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suck abstract from ncbi


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pmid26473639      J+Acquir+Immune+Defic+Syndr 2015 ; 70 (3): 236-41
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  • Coordinated modulation of circulating miR-21 in HIV, HIV-associated pulmonary arterial hypertension, and HIV/HCV co-infection #MMPMID26473639
  • Parikh VN; Park J; Nikolic I; Channick R; Yu PB; De Marco T; Hsue P; Chan SY
  • J Acquir Immune Defic Syndr 2015[Nov]; 70 (3): 236-41 PMID26473639show ga
  • Dysregulation of microRNA-21 (miR-21) is independently associated with human immunodeficiency virus (HIV) infection, pulmonary arterial hypertension (PAH), and hepatitis C virus (HCV) infection. To assess expression of miR-21 in these overlapping comorbidities, we measured plasma miR-21 in HIV with and without PAH and then stratified by concomitant HCV infection. miR-21 was increased in HIV and HIV-PAH versus uninfected subjects, but did not differ between these groups. HIV/HCV co-infection correlated with even higher miR-21 levels within the HIV-infected population. These data reveal specific regulation of plasma miR-21 in HIV, HIV/HCV co-infection, and PAH and suggest that miR-21 may integrate complex disease-specific signaling in the setting of HIV infection.
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