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10.1111/j.1749-6632.2010.05603.x http://scihub22266oqcxt.onion/10.1111/j.1749-6632.2010.05603.x C4610122!4610122!20716293     free     free     free       Ann+N+Y+Acad+Sci 2010 ; 1203 (ä): 120-5 Nephropedia Template TP {{tp|p=20716293|t=2010. Mechanisms of oxidant generation by catalase |pdf=|usr=}}{{20716293}} gab.com Text Mechanisms of oxidant generation by catalase JO: Ann N Y Acad Sci http://www.kidney.de/pget.php?&tw=1&pmid=20716293 #FOAvip The enzyme catalase converts solar radiation into reactive oxidant species (ROS). In this study, we report that several bacterial catalases (hydroperoxidases, HP), including Escherichia coli HP-I and HP-II also generate reactive oxidants in response to ultraviolet B light (UVB). HP-I and HP-II are identical except for the presence of NADPH. We found that only one of the catalases, HPI, produces oxidants in response to UVB light, indicating a potential role for the nucleotide in ROS production. This prompts us to speculate that NADPH may act as a cofactor regulating ROS generation by mammalian catalases. Structural analysis of the NADPH domains of several mammalian catalases revealed that the nucleotide is bound in a constrained conformation and that UVB irradiation induces NADPH oxidation and positional changes. Biochemical and kinetic analysis indicate that ROS formation by the enzyme is enhanced by oxidation of the cofactor. Conformational changes following absorption of UVB light by catalase NADPH have the potential to facilitate ROS production by the enzyme. Twit Text FOAVip Mechanisms of oxidant generation by catalase ????Ann N Y Acad Sci http://www.kidney.de/pget.php?&tw=1&pmid=20716293 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20716293 #FOAvip English Wikipedia <ref>{{Cite pmid|20716293}}</ref> Mechanisms of oxidant generation by catalase #MMPMID20716293 Heck DE; Shakarjian M; Kim HD; Laskin JD; Vetrano AM Ann N Y Acad Sci 2010[Aug]; 1203 (ä): 120-5 PMID20716293show ga The enzyme catalase converts solar radiation into reactive oxidant species (ROS). In this study, we report that several bacterial catalases (hydroperoxidases, HP), including Escherichia coli HP-I and HP-II also generate reactive oxidants in response to ultraviolet B light (UVB). HP-I and HP-II are identical except for the presence of NADPH. We found that only one of the catalases, HPI, produces oxidants in response to UVB light, indicating a potential role for the nucleotide in ROS production. This prompts us to speculate that NADPH may act as a cofactor regulating ROS generation by mammalian catalases. Structural analysis of the NADPH domains of several mammalian catalases revealed that the nucleotide is bound in a constrained conformation and that UVB irradiation induces NADPH oxidation and positional changes. Biochemical and kinetic analysis indicate that ROS formation by the enzyme is enhanced by oxidation of the cofactor. Conformational changes following absorption of UVB light by catalase NADPH have the potential to facilitate ROS production by the enzyme. äMechanisms of oxidant generation by catalase (epmc).pdf DeepDyve Pubget Overpricing