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2015 ; 2015
(ä): 835934
Nephropedia Template TP
gab.com Text
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English Wikipedia
Are Endothelial Progenitor Cells the Real Solution for Cardiovascular Diseases?
Focus on Controversies and Perspectives
#MMPMID26509164
Balistreri CR
; Buffa S
; Pisano C
; Lio D
; Ruvolo G
; Mazzesi G
Biomed Res Int
2015[]; 2015
(ä): 835934
PMID26509164
show ga
Advanced knowledge in the field of stem cell biology and their ability to provide
a cue for counteracting several diseases are leading numerous researchers to
focus their attention on "regenerative medicine" as possible solutions for
cardiovascular diseases (CVDs). However, the lack of consistent evidence in this
arena has hampered the clinical application. The same condition affects the
research on endothelial progenitor cells (EPCs), creating more confusion than
comprehension. In this review, this aspect is discussed with particular emphasis.
In particular, we describe biology and physiology of EPCs, outline their clinical
relevance as both new predictive, diagnostic, and prognostic CVD biomarkers and
therapeutic agents, discuss advantages, disadvantages, and conflicting data about
their use as possible solutions for vascular impairment and clinical
applications, and finally underline a very crucial aspect of EPCs
"characterization and definition," which seems to be the real cause of large
heterogeneity existing in literature data on this topic.