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10.1128/MCB.00512-15 http://scihub22266oqcxt.onion/10.1128/MCB.00512-15 C4609748!4609748!26370509     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell+Biol 2015 ; 35 (22): 3800-9 Nephropedia Template TP {{tp|p=26370509|t=2015. The New State of the Art: Cas9 for Gene Activation and Repression |pdf=|usr=}}{{26370509}} gab.com Text The New State of the Art: Cas9 for Gene Activation and Repression JO: Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26370509 #FOAvip CRISPR-Cas9 technology has rapidly changed the landscape for how biologists and bioengineers study and manipulate the genome. Derived from the bacterial adaptive immune system, CRISPR-Cas9 has been coopted and repurposed for a variety of new functions, including the activation or repression of gene expression (termed CRISPRa or CRISPRi, respectively). This represents an exciting alternative to previously used repression or activation technologies such as RNA interference (RNAi) or the use of gene overexpression vectors. We have only just begun exploring the possibilities that CRISPR technology offers for gene regulation and the control of cell identity and behavior. In this review, we describe the recent advances of CRISPR-Cas9 technology for gene regulation and outline advantages and disadvantages of CRISPRa and CRISPRi (CRISPRa/i) relative to alternative technologies. Twit Text FOAVip The New State of the Art: Cas9 for Gene Activation and Repression ????Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26370509 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26370509 #FOAvip English Wikipedia <ref>{{Cite pmid|26370509}}</ref> The New State of the Art: Cas9 for Gene Activation and Repression #MMPMID26370509 La Russa MF; Qi LS Mol Cell Biol 2015[Nov]; 35 (22): 3800-9 PMID26370509show ga CRISPR-Cas9 technology has rapidly changed the landscape for how biologists and bioengineers study and manipulate the genome. Derived from the bacterial adaptive immune system, CRISPR-Cas9 has been coopted and repurposed for a variety of new functions, including the activation or repression of gene expression (termed CRISPRa or CRISPRi, respectively). This represents an exciting alternative to previously used repression or activation technologies such as RNA interference (RNAi) or the use of gene overexpression vectors. We have only just begun exploring the possibilities that CRISPR technology offers for gene regulation and the control of cell identity and behavior. In this review, we describe the recent advances of CRISPR-Cas9 technology for gene regulation and outline advantages and disadvantages of CRISPRa and CRISPRi (CRISPRa/i) relative to alternative technologies. äThe New State of the Art: Cas9 for Gene Activation and Repression (epmc).pdf DeepDyve Pubget Overpricing